Structural elucidation of T-box–tRNA complexes provides new insights into the mechanisms of tRNA decoding and aminoacylation sensing by T-box riboswitches.

See Li, Su et al., Battaglia et al., Suddala and Zhang

The arginine methyltransferase PRMT5 modifies the splicing regulator SRSF1, which results in alternative splicing of multiple genes essential for the survival of acute myeloid leukemia cells.

See Radzisheuskaya et al.

In this issue, we present a Focus on Targeting Chromatin for therapeutic intervention, with commissioned Reviews, Perspectives and a Comment, highlighting chromatin-based processes as promising targets for therapeutic intervention.

See Editorial

Our mandala cover image reflects the ever-expanding complexity of eukaryotic transcriptional regulation, whose 50-year anniversary we celebrate in this special Focus issue.

See Editorial

The identification of a complex between the RNA-binding protein Nxf2 and the Piwi-associated protein Panoramix, called ‘SFiNX’, demonstrates an RNA export–independent role for Nxf2 in piRNA-guided co-transcriptional transposon silencing.

See Batki, Schnabl, Wang et al. 26, 720–731 (2019)

We launch a Series on Synaptic Processes, featuring commissioned Reviews and opinion pieces that discuss the expanding molecular understanding of how neural cells communicate.

See Editorial 26, 527 (2019)

Otopetrins are proton channels and candidate sour-taste sensors. Cryo-EM, functional and computational analyses reveal the architecture of zebrafish Otop1 and chicken Otop3, as well as potential paths for proton conduction.

See Saotome et al.

Work from the Shao lab reveals that human ANKZF1 severs polypeptidyl-tRNAs on RQC complexes by cleaving the terminal 3'CCA nucleotides, which leads to tRNA fragments that are quality checked and recycled in the cytosol.

See Yip et al. 26, 343-349 (2019)

Single-cell analyses reveal the 3D genome organization of rod photoreceptor cells and olfactory sensory neurons.

See Tan, Xing et al. 26, 297–307 (2019)

Two reports use HiC to probe chromatin organization and dynamics as mammalian spermatocytes progress from early meiotic prophase to mature sperm.

See Patel, Kang et al. and Alavattam et al.

Bulk and single-molecule fluorescence analyses reveal the dynamics of RPA DNA-binding domains during homologous recombination.

See Pokhrel, Caldwell et al. 26, 129–136 (2019)

Two reports reveal that transcription start and stop sites shape DNA replication initiation and termination, and that transcription influences replication patterns to modulate genome stability.

See Chen et al. 26, 67–77 (2018) and Blin et al. 26, 58–66 (2018)