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Recent advances in the ability to detect mRNA base modifications have led to a renewed appreciation for the diversity of the epitranscriptome and its ability to influence gene expression. Now, a study in Cell adds acetylated cytidine (ac4C) to the list, identifying it as a widespread mark in cellular mRNAs that influences both mRNA stability and translation.
Diederichs and colleagues review RNA motifs, focusing on four recent studies identifying nuclear-retention motifs, and discuss the limited specificity of short RNA motifs and the resulting challenge for effective functional prediction.
This Review discusses mechanistic insights into 5´–3´ RNA decay, such as translation–decay coupling, coordination between complexes that process 5´ & 3´ RNA termini, conformational control of enzymatic activity, phase separation, & RNA modifications.
This structure of human PTH1R, a key target for the treatment of osteoporosis, reveals the agonist binding mode and molecular details within conserved structural motifs critical for class B GPCR function.
Point centromeres of budding yeast direct binding of a CBF3 complex that recruits the centromere-specific Cse4 nucleosome to CEN loci. A cryo-EM structure of CBF3 bound to its cognate CDEIII element and a model of the CBF3–Cse4–CEN complex reveal interactions underlying kinetochore assembly.
Rubinstein and colleagues report a structure of the obligate respiratory III2IV2 supercomplex from M. smegmatis, revealing two functionally relevant conformations of the cytochrome cc subunit and a SOD subunit that may detoxify reactive oxygen species.