Volume 25 Issue 12, December 2018

Volume 25 Issue 12

Order in cell division

A PxL motif functions as a docking motif for substrates of yeast phosphatase Cdc14, contributing to the proper timing of dephosphorylation and ensuring orderly mitotic exit.

See Kataria et al. 25, 1093–1102 (2018)

Image: Meghna Kataria/Jeroen Claus (Phospho Biomedical Animation). Cover Design: Erin Dewalt.

Correspondence

Obituary

News & Views

  • News & Views |

    Recent advances in the ability to detect mRNA base modifications have led to a renewed appreciation for the diversity of the epitranscriptome and its ability to influence gene expression. Now, a study in Cell adds acetylated cytidine (ac4C) to the list, identifying it as a widespread mark in cellular mRNAs that influences both mRNA stability and translation.

    • Seung H. Choi
    •  & Kate D. Meyer

Perspectives

Review Articles

Articles

  • Article |

    Point centromeres of budding yeast direct binding of a CBF3 complex that recruits the centromere-specific Cse4 nucleosome to CEN loci. A cryo-EM structure of CBF3 bound to its cognate CDEIII element and a model of the CBF3–Cse4–CEN complex reveal interactions underlying kinetochore assembly.

    • Kaige Yan
    • , Ziguo Zhang
    • , Jing Yang
    • , Stephen H. McLaughlin
    •  & David Barford
  • Article |

    Single-molecule magnetic tweezers analyses and supporting MD simulations provide evidence for protein-gate opening of type IA topoisomerases.

    • Maria Mills
    • , Yuk-Ching Tse-Dinh
    •  & Keir C. Neuman
  • Article |

    A combination of proteomics and structural analyses reveals the assembly mechanism of transcription factor TFIID in human cells and identifies the chaperonin CCT as a checkpoint in the process.

    • Simona V. Antonova
    • , Matthias Haffke
    • , Eleonora Corradini
    • , Mykolas Mikuciunas
    • , Teck Y. Low
    • , Luca Signor
    • , Robert M. van Es
    • , Kapil Gupta
    • , Elisabeth Scheer
    • , Harmjan R. Vos
    • , László Tora
    • , Albert J. R. Heck
    • , H. T. Marc Timmers
    •  & Imre Berger
  • Article |

    Rubinstein and colleagues report a structure of the obligate respiratory III2IV2 supercomplex from M. smegmatis, revealing two functionally relevant conformations of the cytochrome cc subunit and a SOD subunit that may detoxify reactive oxygen species.

    • Benjamin Wiseman
    • , Ram Gopal Nitharwal
    • , Olga Fedotovskaya
    • , Jacob Schäfer
    • , Hui Guo
    • , Qie Kuang
    • , Samir Benlekbir
    • , Dan Sjöstrand
    • , Pia Ädelroth
    • , John L Rubinstein
    • , Peter Brzezinski
    •  & Martin Högbom

Amendments & Corrections