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Volume 24 Issue 2, February 2017

Structures of human APOBEC3A and an APOBEC3A/3B chimera bound to ssDNA reveal a U-shaped binding mode and provide insight into target selectivity. Cover shows the Moselschleife bei Bremm. Cover art by Erin Dewalt, image from studioworxx / iStock / Getty Images Plus. (p 131, News and Views p 97)

News & Views

  • Targeted deamination of cytosine bases in DNA by AID/APOBEC-family enzymes is critical for proper immune function, but it also poses risks to genomic integrity. New structures reported by Harris, Aihara and colleagues offer the first glimpses into the enzyme–DNA complex and reveal both expected and unexpected insights into the DNA-binding mode involved in targeting purposeful mutation.

    • Emily K Schutsky
    • Zachary M Hostetler
    • Rahul M Kohli
    News & Views


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