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Volume 22 Issue 6, June 2015

Volume 22 Issue 6

Competition of CRY1 with coactivators for binding to the BMAL1 transcriptional activation domain regulates circadian cycling.Cover image by © Ryan McVay /Photodisc / Thinkstock (pp 476–484, News and Views p 435)


News & Views

  • News & Views |

    How do molecular interactions determine the period length of a circadian oscillator? In mammals, a disordered region of the BMAL1 transcription factor that is able to interact with activators or repressors seems to perform this function.

    • Ka Yi Hui
    • Jürgen A Ripperger
  • News & Views |

    Sex-determining transcription factors recognize their genomic target sites through mechanisms of DNA base-and-shape readout in combination with cooperative binding. Murphy et al. reveal that for one such transcription factor, DMRT1, the DNA sequence-and-shape features of its binding sites determine whether it binds DNA as a dimer, trimer or tetramer; they also characterize protein-DNA contacts that affect gender phenotypes in flies and humans.

    • Remo Rohs
    • Ana Carolina Dantas Machado
    • Lin Yang
  • News & Views |

    Ten years ago, the repulsive guidance molecules (RGMs), a family of three glycosylphosphatidylinositol–anchored glycoproteins, were identified as highly specific co-receptors of the bone morphogenetic proteins (BMPs). Newly reported crystal structures provide exciting insights into how RGM co-receptors may modulate BMP signaling.

    • Thomas D Mueller

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