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Volume 13 Issue 2, February 2006

Yama is the God of Death revered in Tibetan Buddhism. While his western counterpart, The Grim Reaper, is typically personified as an old man or a skeleton with a scythe, Yama has different manifestations, one of which is shown here (photo courtesy of R. Mann). The protein Reaper activates apoptotic proteases and is involved in translation inhibition. Colon-Ramos et al. show that Reaper directly associates with the ribosomal 40S subunit and probably interferes with its recognition of the start codon. pp 103-111


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News & Views

  • Some membrane proteins can adopt multiple topologies, forcing us to think more expansively about membrane protein architecture.

    • James U Bowie
    News & Views
  • A recent study shows that the Mediator complex is not universally recruited to the promoters of actively transcribed genes in yeast, suggesting that the requirement for Mediator in transcription activation is an activator-dependent property.

    • Brian A Lewis
    • Danny Reinberg
    News & Views
  • A recent study shows that the Drosophila melanogaster proapoptotic protein Reaper inhibits protein synthesis by direct binding to 40S ribosomal subunits, which affects recognition of initiation codons and ribosomal subunit joining.

    • Tatyana V Pestova
    • Christopher U T Hellen
    News & Views
  • Recent publications suggest that certain proteins of the Polycomb group interact with DNA methyltransferases. This may connect the two systems that are known to mediate somatic inheritance of states of gene expression during development.

    • Marc Damelin
    • Steen K T Ooi
    • Timothy H Bestor
    News & Views
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Brief Communication

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