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Aging: rewiring the circadian clock

Nature Structural & Molecular Biology volume 24, pages 687–688 (2017)Cite this article

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The robustness of the circadian clock deteriorates with aging. Two new studies show that aging reprograms the circadian transcriptome in a cell-type-dependent manner and that such rewiring can be reversed by caloric restriction.

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Figure 1: Aging reprograms the circadian transcriptome in a cell-type-dependent manner.

Kimberly Caesar/Springer Nature

References

  1. Luo, H., Chiang, H.H., Louw, M., Susanto, A. & Chen, D. Trends Endocrinol. Metab. 28, 449–460 (2017).

    Article  CAS  Google Scholar 

  2. Weindruch, R. & Walford, R.L. The Retardation of Aging and Disease by Dietary Restriction (Charles C. Thomas Publisher, 1988).

  3. Chen, D., Steele, A.D., Lindquist, S. & Guarente, L. Science 310, 1641 (2005).

    Article  CAS  Google Scholar 

  4. Qiu, X., Brown, K., Hirschey, M.D., Verdin, E. & Chen, D. Cell Metab. 12, 662–667 (2010).

    Article  CAS  Google Scholar 

  5. Sato, S. et al. Cell 170, 664–677 (2017).

    Article  CAS  Google Scholar 

  6. Solanas, G. et al. Cell 170, 678–692 (2017).

    Article  CAS  Google Scholar 

  7. Brown, K. et al. Cell Rep. 3, 319–327 (2013).

    Article  CAS  Google Scholar 

  8. Goodell, M.A. & Rando, T.A. Science 350, 1199–1204 (2015).

    Article  CAS  Google Scholar 

  9. Mohrin, M. et al. Science 347, 1374–1377 (2015).

    Article  CAS  Google Scholar 

  10. Kondratov, R.V., Kondratova, A.A., Gorbacheva, V.Y., Vykhovanets, O.V. & Antoch, M.P. Genes Dev. 20, 1868–1873 (2006).

    Article  CAS  Google Scholar 

  11. Nakamura, T.J. et al. J. Neurosci. 31, 10201–10205 (2011).

    Article  CAS  Google Scholar 

  12. Sellix, M.T. et al. J. Neurosci. 32, 16193–16202 (2012).

    Article  CAS  Google Scholar 

  13. Geyfman, M. et al. Proc. Natl. Acad. Sci. USA 109, 11758–11763 (2012).

    Article  CAS  Google Scholar 

  14. Stringari, C. et al. Cell Rep. 10, 1–7 (2015).

    Article  CAS  Google Scholar 

  15. Finkel, T., Deng, C.X. & Mostoslavsky, R. Nature 460, 587–591 (2009).

    Article  CAS  Google Scholar 

  16. Kanfi, Y. et al. Nature 483, 218–221 (2012).

    Article  CAS  Google Scholar 

  17. Shin, J. et al. Cell Rep. 5, 654–665 (2013).

    Article  CAS  Google Scholar 

  18. Masri, S. & Sassone-Corsi, P. Sci. Signal. 7, re6 (2014).

    Article  Google Scholar 

  19. López-Otín, C., Blasco, M.A., Partridge, L., Serrano, M. & Kroemer, G. Cell 153, 1194–1217 (2013).

    Article  Google Scholar 

  20. Vijg, J. & Campisi, J. Nature 454, 1065–1071 (2008).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

D.C. is supported by NIH grant R01DK101885, the National Institute of Food and Agriculture, the PackerWentz Endowment and the Chau Hoi Shuen Foundation. R.O. is supported by the ITO Scholarship and the Honjo International Scholarship.

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  1. the Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, California, USA

    Rika Ohkubo & Danica Chen

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  1. Rika Ohkubo
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  2. Danica Chen
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Correspondence to Danica Chen.

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Ohkubo, R., Chen, D. Aging: rewiring the circadian clock. Nat Struct Mol Biol 24, 687–688 (2017). https://doi.org/10.1038/nsmb.3461

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