C-type inactivation is a process by which ion flux through a voltage-gated K+ channel is regulated at the selectivity filter. A recent structure of the Kv1.2 channel provides a view into the structural changes of the selectivity filter during C-type inactivation.
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Research in my laboratory is supported by a grant from the NIH (GM087546).
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Valiyaveetil, F. A glimpse into the C-type-inactivated state for a Potassium Channel. Nat Struct Mol Biol 24, 787–788 (2017). https://doi.org/10.1038/nsmb.3480
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DOI: https://doi.org/10.1038/nsmb.3480