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  • Focus |

    The fusion of biological membranes is a controlled process that occurs when two closely apposed membrane compartments are brought together so that their contents can be mixed. Membrane fusion is critical for communication between membrane-bound compartments in eukaryotic cells and is essential for host cell infection by enveloped viruses. This special focus on membrane fusion, comprised of an Essay and five Reviews, describes fundamental fusion processes and the interactions that regulate them.

  • Focus |

    In eukaryotes, the packaging of DNA by histones into chromatin has profound effects on transcription and other nuclear processes. Far from being a uniform set of 'beads on a string', chromatin structure is remodeled and even modified, altering the accessibility of packaged genes to the factors involved in their regulation. This special focus on chromatin features an Overview, six Reviews and a Perspective that describe how chromatin is built and subsequently altered at various structural levels, and the impact of these events on fundamental biological processes involving DNA.

  • Focus |

    Ion channels play important roles in a variety of processes in almost all cells, from sensing membrane pressure to neurotransmission. Since the first structure of a potassium channel was reported nearly 10 years ago, improvements in methods have provided us with additional high-resolution views of ion channels, which have informed and guided mechanistic studies. This focus highlights emerging insights into these important molecules obtained from the most current structural and functional studies. The library of Nature Research articles compiles recent work in the ion channel field

  • Milestone |

    Milestones in Gene Expression is a collaborative project involving six journals - Nature,Nature Cell Biology,Nature Genetics,Nature Reviews Genetics,Nature Reviews Molecular Cell BiologyandNature Structural & Molecular Biology- and celebrates almost 50 years of discoveries in the field of transcription and chromatin.

  • Focus |

    Two sets of comprehensive reviews answer the questions of 'who? what? why? when? and how?' about the high-throughput, genome-wide structural analyses efforts across the globe.

  • Focus |

    The reviews in the second NMR supplement focus on the unique capability of NMR to study the dynamics of biomolecules and on the development of non-NOE-based methods to extract structural information

  • Focus |

    A series of reports provide an overview of the synchrotron radiation facilities and highlight the progress from various types of research projects facilitated by the use of synchrotron radiation.

  • Focus |

    The first NMR supplement contains reviews that discuss technological breakthroughs in using NMR for structure determination, as well as an online resource for NMR structural biologists