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Husmann and Gozani review the biochemical and biological activities of histone lysine methyltransferases and their connections to human diseases, focusing on cancer.
Zaware and Zhou review the current understanding of bromodomain biology and discuss the latest development of small-molecule inhibitors that target these protein domains as emerging therapies for cancer and inflammatory disorders.
This review proposes an up-to-date, consensus thermodynamic model for the conformational changes associated with transport by the eukaryotic type I exporters from the ABC family and discusses structural insights into ABC transporter pharmacology.
In this Review, Bob Roeder offers a personal, historical perspective of the landmark studies that elucidated the mechanism and regulation of eukaryotic transcription over five decades, from the initial discovery of three nuclear RNA polymerases to the structural, genomic and imaging approaches that continue to expand our understanding of the function of complex regulatory networks.
Bryan Roth reviews how insights into the structures of G protein–coupled receptors that are targets of neuropsychiatric drugs contribute to understanding of their functions as well as to the discovery of new chemical tools and drugs.
Monoamine transporters (MATs) regulate neurotransmission via the reuptake of dopamine, serotonin and norepinephrine from the extra-neuronal space. This Review discusses recent advances in elucidating the structural dynamics and allosteric regulation of MATs.
Numerous proteins in dendrites and axons are synthesized locally. In this Review, the authors summarize current evidence for local mRNA translation in neurons and discuss the neuronal functions shown to be served by this process.
