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Gabapentinoid drugs are widely used for pain, epilepsy and mental disorders. Chen et al. report the structure of a gabapentin-bound brain and heart calcium channel, revealing the gabapentin binding site and isoform-selective binding determinants.
Here the authors use cryo-EM and biochemical analysis to show how the ancillary protein TPR-CHAT regulates the nuclease function of the CRISPR-guided nuclease Cas7-11.
A cryo-EM structure of disease-related human Y145Stop prion protein amyloid fibrils explains species-dependent seeding barriers in prion protein amyloid propagation.
Kottur et al. present high-resolution structures of SARS-CoV-2 nsp14 N7-MTase that will aid in the development of new antivirals against this and other pathogenic coronaviruses.
AlphaFold2 predictions, X-ray crystallography and cryo-EM analyses reveal how related human glycoproteins GP2 and uromodulin catch pathogenic bacteria by presenting a high-mannose glycan that acts as a decoy for fimbrial adhesin FimH.
An online and interactive G-protein coupled receptor (GPCR) structure analysis platform allows any researcher to analyze and visualize a plethora of structure–function relationships across the scales of atomic interactions to protein backbone rearrangements.
The cryo-EM structure of DNA-assembled histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus, a nucleocytoplasmic large DNA virus, reveals that these proteins form viral nucleosomes with highly conserved features when compared to canonical eukaryotic nucleosomes.
The SARS-CoV-2 spike ectodomain is destabilized by cold temperature storage, an effect that can be reversed by incubation at 37 °C or by stabilizing its conformation in the ‘down’ state.
A crystal structure of SARS-CoV-2 with inhibitor carmofur reveals the mechanism of action of this compound and opens the way to develop more potent drugs.
The structure of the second zinc finger of SALL4 in complex with pomalidomide, cereblon and DDB1 reveals the unique details of SALL4 recruitment, providing insights for rational design of cereblon-binding drugs with reduced teratogenic risk.
The structure of human SMG1–SMG8–SMG9, a PI(3)K-related protein kinase complex central to mRNA surveillance, uncovers an InsP6-binding site in the SMG1 kinase that is conserved in mTOR and important for kinase activity.
Cryo-EM structures of mouse TRPV3 in open, closed and intermediate states, obtained by incubation of the protein samples at different temperatures immediately prior to freezing, offer insight into conformational changes induced by heat in TRPV3.
Crystal structure of the tubulin carboxypeptidase complex between vasohibin and SVBP, combined with mutagenesis, reveals the residues responsible for substrate recognition and cleavage.
The cryo-EM structure of the human core CPSF complex, containing CPSF160, WDR33, CPSF30 and Fip1 subunits, bound to its RNA target reveals the mechanism of PAS recognition.
MicroED structure of a peptide from the β2–α2 loop of the bank vole prion protein reveals a protofibril stabilized by a dense network of hydrogen bonds.
MILI-mediated piRNA processing and amplification is not essential for all MIWI2 male germline reprogramming activity, indicating the existence of a MILI-independent piRNA biogenesis pathway.
The crystal structure of the phage anti-CRISPR protein AcrF3 in complex with Cas3 reveals its mode of inhibition of the CRISPR–Cas bacterial immune system.
The crystal structure of full-length NS1 protein from Zika virus reveals an extended surface for membrane association and a highly variable polar surface.
The complete architecture of the yeast COG tethering complex is revealed by negative-stain electron microscopy, showing an intricate shape with up to five flexible legs.
