Strings of beads, in different colours.

Advancing the mechanistic understanding of writers and readers of ubiquitylation

In this issue, we feature studies progressing our understanding of writers and readers of ubiquitylation, and several pieces reflecting on the ever-expanding roles of this critical modification.



  • NSMB cover

    January 2024 marks 30 years since we published the first volume of NSMB. We will be celebrating this milestone throughout 2024, reflecting on the road covered and looking towards the future.

  • NSMB cover first issue

    In January 2024, NSMB will celebrate the 30th anniversary of publishing its first issue. To celebrate, we would like to give our readers, center stage and invite you to send us your comments and letters to the editors, reflecting both on the past and the upcoming years. Details:

Nature Structural & Molecular Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • Using deep mutational scanning, the authors uncover the functional consequence of missense mutations in ARID1B, a subunit of the SWI/SNF chromatin remodeling complex that is frequently mutated in human Coffin–Siris syndrome and in cancer.

    • Fanny Mermet-Meillon
    • Samuele Mercan
    • Giorgio G. Galli
    Brief CommunicationOpen Access
  • Kalienkova et al. use cryo-electron microscopy to capture 3D structures of a neuropeptide-gated DEG/ENaC ion channel in resting and ligand-bound states, detailing the mechanism by which peptides activate these excitatory ion channels.

    • Valeria Kalienkova
    • Mowgli Dandamudi
    • Timothy Lynagh
    ArticleOpen Access