Single worm (Malacoceros fuliginosus)

Disentangling channel gating mechanisms

Kalienkova et al. report structures of an FMRFamide-gated sodium channel (FaNaC) in several functional states, disentangling how different invertebrate receptors recognize similar neuropeptides.

  • Valeria Kalienkova
  • Mowgli Dandamudi
  • Timothy Lynagh


  • NSMB cover

    January 2024 marks 30 years since we published the first volume of NSMB. We will be celebrating this milestone throughout 2024, reflecting on the road covered and looking towards the future.

  • NSMB cover first issue

    In January 2024, NSMB will celebrate the 30th anniversary of publishing its first issue. To celebrate, we would like to give our readers, center stage and invite you to send us your comments and letters to the editors, reflecting both on the past and the upcoming years. Details:

Nature Structural & Molecular Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • Since Nature Structural and Molecular Biology was started 30 years ago, our understanding of transcription and mRNA processing has been revolutionized through structural and mechanistic studies. Here, we present our personal views of the advances in understanding the production of mature eukaryotic mRNAs over the past decade.

    • Lori A. Passmore
    • Suyang Zhang
  • The first membrane protein structure was reported almost 40 years ago. In this issue, we are publishing a set of papers that serve to underline the incredible advances in our understanding of the biology of these multifaceted molecular machines.

  • G protein-coupled receptors (GPCRs) with no known endogenous ligand are termed orphans. Deorphanization of a GPCR involves identifying the ligand, which can be a painstaking exercise. In this Comment, we discuss the challenges in the process, its role in drug discovery and alternative approaches to characterizing orphan GPCRs.

    • Nicola J. Smith
    • Fiona Murray
  • The identification of sodium and potassium currents as underlying action potential propagation, more than 70 years ago, opened a new avenue of research into the role of ion channels. In this Comment, we present our personal perspectives of the field, from the identification of Shaker as a potential potassium channel to the mechanistic insights available to us today.

    • Lily Yeh Jan
    • Yuh Nung Jan
  • In addition to the usual dose of compelling science, our March issue features thoughtful reflections on the last 30 years from readers, as well as past and present editors. Perhaps influenced by these pieces or by our stunning cover — or maybe it is just the changing seasons — we are in an introspective mood this month.

  • Over the past 30 years, Nature Structural & Molecular Biology (NSMB) has covered an enormous breadth of subjects in the broad field of molecular and structural biology. Here, some of the journal’s past and present editors recount their editorial experience at NSMB and some of the more memorable papers they worked on.

    • Guy Riddihough
    • Christopher Surridge
    • Dimitris Typas