Browse our December issue

Latest Research

  • Review Article |

    Zhou, Gaullier and Luger review insights derived from cutting-edge biophysical and structural approaches applied to the study of nucleosome dynamics and nucleosome-binding factors, with a focus on the experimental advances driving the research.

    • Keda Zhou
    • , Guillaume Gaullier
    •  & Karolin Luger
  • Article |

    Rubinstein and colleagues report a structure of the obligate respiratory III2IV2 supercomplex from M. smegmatis, revealing two functionally relevant conformations of the cytochrome cc subunit and a SOD subunit that may detoxify reactive oxygen species.

    • Benjamin Wiseman
    • , Ram Gopal Nitharwal
    • , Olga Fedotovskaya
    • , Jacob Schäfer
    • , Hui Guo
    • , Qie Kuang
    • , Samir Benlekbir
    • , Dan Sjöstrand
    • , Pia Ädelroth
    • , John L Rubinstein
    • , Peter Brzezinski
    •  & Martin Högbom
  • Article |

    A combination of proteomics and structural analyses reveals the assembly mechanism of transcription factor TFIID in human cells and identifies the chaperonin CCT as a checkpoint in the process.

    • Simona V. Antonova
    • , Matthias Haffke
    • , Eleonora Corradini
    • , Mykolas Mikuciunas
    • , Teck Y. Low
    • , Luca Signor
    • , Robert M. van Es
    • , Kapil Gupta
    • , Elisabeth Scheer
    • , Harmjan R. Vos
    • , László Tora
    • , Albert J. R. Heck
    • , H. T. Marc Timmers
    •  & Imre Berger
  • Article |

    Point centromeres of budding yeast direct binding of a CBF3 complex that recruits the centromere-specific Cse4 nucleosome to CEN loci. A cryo-EM structure of CBF3 bound to its cognate CDEIII element and a model of the CBF3–Cse4–CEN complex reveal interactions underlying kinetochore assembly.

    • Kaige Yan
    • , Ziguo Zhang
    • , Jing Yang
    • , Stephen H. McLaughlin
    •  & David Barford

News & Comment

Series

NSMB 25

We mark the 25th year of NSMB with a special Series of commissioned Reviews and Comments that celebrate exciting research uncovering the fundamental principles behind biological processes.