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Sexual dysfunction in 2015

Recovering sex drive in women — progress and opportunities

Nature Reviews Urology volume 13, pages 67–68 (2016)Cite this article

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In 2015, the approval of flibanserin opened a debate about diagnosis and treatment of female sexual dysfunction. Designing clinical trials with suitable end points is difficult, but some studies indicate correlations between hormone levels and low desire. New research demonstrates opportunities for a better understanding of this multifaceted condition.

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References

  1. Stahl, S. M. Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorder. CNS Spectr. 20, 1–6 (2015).

    Article  Google Scholar 

  2. Thorp, J. Jr, Palacios, S., Symons, J., Simon, J. & Barbour, K. Improving prospects for treating hypoactive sexual desire disorder (HSDD): development status of flibanserin. BJOG 121, 1328–1331 (2014).

    Article  CAS  Google Scholar 

  3. Pyke, R. E. & Clayton, A. H. Psychological treatment trials for hypoactive sexual desire disorder: a sexual medicine critique and perspective. J. Sex. Med. 12, 2451–2458 (2015).

    Article  Google Scholar 

  4. Sungur, M. Z. & Gündüz, A. A comparison of DSM-IV-TR and DSM-5 definitions for sexual dysfunctions: critiques and challenges. J. Sex. Med. 11, 364–373 (2014).

    Article  Google Scholar 

  5. Sarin, S., Amsel, R. & Binik, Y. M. How hot is he? A psychophysiological and psychosocial examination of the arousal patterns of sexually functional and dysfunctional men. J. Sex. Med. 11, 1725–1740 (2014).

    Article  Google Scholar 

  6. Portman, D. J., Edelson, J., Jordan, R., Clayton, A. & Krychman, M. L. Bremelanotide for hypoactive sexual desire disorder: analyses from a phase 2B dose-ranging study. Obstet. Gynecol. 123, 31S (2014).

    Article  Google Scholar 

  7. Wierman, M. E. et al. Androgen therapy in women: a reappraisal: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 99, 3489–3510 (2014).

    Article  CAS  Google Scholar 

  8. Cunningham, G. R. et al. Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials. J. Clin. Endocrinol. Metab. 100, 1146–1155 (2015).

    Article  CAS  Google Scholar 

  9. Wåhlin-Jacobsen, S. et al. Is there a correlation between androgens and sexual desire in women? J. Sex. Med. 12, 358–373 (2015).

    Article  Google Scholar 

  10. Randolph, J. F. Jr, Zheng, H., Avis, N. E., Greendale, G. A. & Harlow, S. D. Masturbation frequency and sexual function domains are associated with serum reproductive hormone levels across the menopausal transition. J. Clin. Endocrinol. Metab. 100, 258–266 (2015).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical, Rossella E. Nappi is at the Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS S. Matteo Foundation, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.,

    Rossella E. Nappi

  2. Francesca Albani is at the Unit of Internal Medicine and Endocrinology, IRCCS Foundation S. Maugeri, Via Ferrata 8, 27100 Pavia, Italy.,

    Francesca Albani

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  1. Rossella E. Nappi
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  2. Francesca Albani
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Correspondence to Rossella E. Nappi.

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Competing interests

R.E.N. had financial relationships (lecturer, member of advisory boards and/or consultant) with Bayer HealthCare, Boehringer Ingelheim, Ely Lilly, Endoceutics, Gedeon Richter, HRA Pharma, Merck Sharpe & Dohme, Novo Nordisk, Pfizer, Procter & Gamble, Shionogi Limited and TEVA Women's Health. F.A. declares no conflicts of interest.

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Nappi, R., Albani, F. Recovering sex drive in women — progress and opportunities. Nat Rev Urol 13, 67–68 (2016). https://doi.org/10.1038/nrurol.2015.314

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