News & Views

Filter By:

  • New evidence suggests that patients undergoing robotic-assisted radical cystectomy for non-metastatic bladder cancer experience better response in terms of days alive and out of the hospital than patients undergoing open radical cystectomy. The robotic approach was associated with improved post-operative mobilization, decreased transfusion requirement and reduced burden on perceived quality of life.

    • Sagar R. Patel
    • Seth P. Lerner
    News & Views
  • Immune system activation is necessary for BCG-mediated tumour immunity in non-muscle-invasive bladder cancer. However, mounting evidence supports the notion that dysfunctional activation, in the form of immune exhaustion, might contribute to BCG failure. Thus, an exhaustion signature, arising in treated tumours, could act as a predictive marker for BCG therapy.

    • Molly A. Ingersoll
    News & Views
  • Genetics has a role in predisposition towards prostate cancer, and an accurate prediction of prostate cancer risk can be made using polygenic risk scores. New evidence suggests that this risk is modifiable through lifestyle changes, but only in men at a high genetic risk of developing prostate cancer.

    • Stephen J. Freedland
    • Nadine (Adriana) Friedrich
    News & Views
  • Muscle-invasive bladder cancer (MIBC) remains a deadly disease, despite aggressive surgical and systemic chemotherapeutic treatments. New treatment modalities are needed. A novel intravesicle drug delivery device for neoadjuvant treatment of MIBC has been developed, and preliminary results on the efficacy and safety of this system are available.

    • Katherine M. Rodriguez
    • Max Kates
    News & Views
  • The BIONIKK trial is the first prospective biomarker-driven randomized trial in metastatic clear cell renal cell carcinoma. This trial demonstrates the feasibility of using a transcriptomic biomarker that reflects intrinsic disease biology to optimize treatment efficacy and shows that all patients might not require combination treatment.

    • Eduard Roussel
    • Benoit Beuselinck
    • Maarten Albersen
    News & Views
  • The highest risk of death from prostate cancer is associated with increased waist circumference, increased blood pressure, hypertension, type 2 diabetes and obesity; thus, therapies that can reduce blood glucose levels have the potential to improve patient outcomes. The therapeutic benefits of low-carbohydrate and fasting-mimicking diets in patients with prostate cancer have been investigated in two recent studies.

    • Thomas N. Seyfried
    News & Views
  • Prognostic models incorporating clinical and pathological parameters might assist clinicians in counselling and surveillance of patients following surgical resection of renal cell carcinoma (RCC). Variability exists in the risk classification of individual patients in each model as well as the performance of each model in different RCC subtypes.

    • Thomas Gerald
    • Vitaly Margulis
    News & Views
  • The extent, duration and causes of alterations in the testes caused by SARS-CoV-2 are unclear. A new study has documented the effects of SARS-CoV-2 infection on the testes of a golden Syrian hamster model; however, the relevance of these findings to non-severe human infection is questionable.

    • Nathalie Dejucq-Rainsford
    News & Views
  • Artificial intelligence (AI)-based models can potentially reduce workload and assist general pathologists in reaching genitourinary pathologists’ performance. A recent large-scale competition to develop generalizable AI models for prostate cancer detection and grading has shown success; implementation of such models positions them beyond hype and as today’s reality.

    • Ali Bashashati
    • S. Larry Goldenberg
    News & Views
  • Sexual adverse effects from prostate cancer treatment are a substantial burden for patients. An online biopsychosocial sexual rehabilitation intervention for patients with prostate cancer (TrueNTH) was implemented in several cancer centres in the USA. Outcomes from this intervention show no improvements in sexual satisfaction after 6 months; however, earlier resumption of sexual activities was observed 3 months after the intervention.

    • Lauren M. Walker
    News & Views
  • Genitourinary microorganisms could have detrimental effects on male fertility owing to increased production of reactive oxygen species and generation of oxidative stress, which can lead to sperm DNA damage. Diagnostic genitourinary microorganism screening could help in understanding the reasons for infertility and refine infertility diagnosis and treatment.

    • Signe Altmäe
    • Tiiu Kullisaar
    News & Views
  • Prognostic models are crucial for optimal management of patients with renal cell carcinoma (RCC) after surgery. Multiple clinico-pathological models to predict cancer outcomes in these patients exist and seem to have reached their performance ceiling. Future research needs to identify new prognostic markers and to consider when and how prognostic models for RCC are implemented into practice.

    • Juliet A. Usher-Smith
    • Grant D. Stewart
    News & Views
  • Robotic-assisted radical prostatectomy has similar oncological outcomes to open retropubic prostatectomy, but improved potency outcomes. Surgeon skill and degree of nerve sparing, patient age and preoperative potency are the greatest predictors of postoperative potency outcomes. Bhat and colleagues present potency and quality-of-life outcomes from a very high-volume robotic surgery study.

    • Sophie J. Tissot
    • Anthony J. Costello
    News & Views
  • Sperm characteristics are routinely assessed in fertility clinics as decisive factors to select sperm for improved intracytoplasmic sperm injection (ICSI) outcomes. A recent study suggests that, in patients with non-obstructive azoospermia, no specific defect or combination of abnormalities in testicular sperm precluded chance of pregnancy, while also suggesting sperm motility and acrosome defects are the proxies relevant to ICSI outcomes.

    • Reza Nosrati
    • David Sinton
    News & Views
  • A striking disproportionate burden of prostate cancer incidence and mortality exists between men of West African ancestry and men of European ancestry. Identifying distinct tumour genetic biomarkers and immunomodulating signals in patients with diverse genetic ancestry might reduce the disparities in prostate cancer prognosis, treatment outcomes and mortality in high-risk racial groups.

    • Jabril R. Johnson
    • Rick A. Kittles
    News & Views
  • Trends in vasectomy use are controversial, but rates might be declining over time. Several factors could contribute to this apparent decrease, which warrant consideration before definitive conclusions are made.

    • Nahid Punjani
    • Marc Goldstein
    News & Views
  • Multidrug-resistant Neisseria gonorrhoeae is a global health problem, and the development of a vaccine is considered essential for the effective control of gonorrhoea. The use of outer membrane vesicle vaccines to prevent N. gonorrhoeae infection has garnered considerable interest, and a recent study using a mouse model of experimental gonococcal infections adds support for this approach.

    • Evgeny A. Semchenko
    • Kate L. Seib
    News & Views
  • Andolfi et al. report on the largest single-institution case series of robot-assisted laparoscopic pyeloplasty (RAL-P) in infants. Transitioning from RAL-P in older children to infants seems to have more to do with patient and port positioning, instrument size and intra-abdominal space than robotic surgical technique.

    • Marie-Klaire Farrugia
    News & Views