Browse Articles

  • Review Article |

    Increasing evidence suggests that patients undergoing trimodality bladder-preserving treatment (TMT) and radical cystectomy have comparable outcomes but many continue to be offered surgery. This Review discusses the development of TMT and highlights how technological and biological advances could inform personalized treatment strategies.

    • Yee Pei Song
    • , Alan McWilliam
    • , Peter J. Hoskin
    •  & Ananya Choudhury
  • News & Views |

    Immune checkpoint therapy is beneficial for patients with advanced bladder cancer; however, trials generally exclude patients with comorbidities or uncommon histologies. The SAUL trial demonstrates that atezolizumab is safe and efficacious in a patient population that more accurately reflects the real-world scenario, but its benefit might still be limited in historically poorly performing populations.

    • Tyler F. Stewart
    •  & Daniel P. Petrylak
  • News & Views |

    The concept that resistance against androgen receptor (AR) signalling inhibitors is explained by AR variants (ARVs) has spread as a seductive meme. However, two problems have delayed the translation of these findings to clinical practice: the complexity of the mechanism of action and the challenging development of clinical decision-making tools involving ARVs.

    • Florian Handle
    •  & Frank Claessens
  • News & Views |

    A new ecological analysis has shown that antimicrobial consumption is positively associated with decreased antimicrobial susceptibility in Neisseria gonorrhoeae across European countries. Efforts at the policy, provider and community level need to be strengthened to address and help mitigate the continued emergence of antimicrobial resistance in N. gonorrhoeae.

    • Huan V. Dong
    •  & Jeffrey D. Klausner
  • Review Article |

    Tissue engineering using different cell types and tissue scaffolds offers a promising alternative to substitution urethroplasty, which can be associated with complications, restenosis and poor quality of life. In this Review, the authors describe advances in tissue engineering for urethral replacement and consider the future of the field.

    • Filippo Pederzoli
    • , Gregory Joice
    • , Andrea Salonia
    • , Trinity J. Bivalacqua
    •  & Nikolai A. Sopko
  • Review Article |

    In this Review, the authors discuss the emerging oncogenic roles of long non-coding RNAs in prostate, kidney and bladder cancers, highlighting unique opportunities to improve diagnosis, treatment and precision medicine strategies in these genitourinary malignancies.

    • Ronan Flippot
    • , Guillaume Beinse
    • , Alice Boilève
    • , Julien Vibert
    •  & Gabriel G. Malouf
  • News & Views |

    A new study describes antitumour cell activity inherent in the extracellular matrix of porcine urinary bladder, which is not the result of direct tumour cell killing but is indirectly mediated through immune cells. The findings highlight opportunities to explore shared interests of the tissue engineering and regenerative medicine and the immunology and cancer communities.

    • Stephen F. Badylak
  • Review Article |

    In this Review, Amarasekera and colleagues consider the effect of prostate cancer diagnosis and treatment on men in sexual minority groups, including men who have sex with men and transgender women as well as men with HIV, and discuss how and why efforts to study this population are complicated and evolving.

    • Channa Amarasekera
    • , Vincent Wong
    • , Emily Yura
    • , Adarsh Manjunath
    • , Edward Schaeffer
    •  & Shilajit Kundu
  • Review Article |

    Urinalysis has long been used as a tool for managing diseases, but 21st century techniques have enabled measurement of metabolomic urinary cancer biomarkers using NMR and mass spectrometry. In this Review, the authors discuss the current status of research developments and offer recommendations to help systematize future research in the field.

    • Sarah S. Dinges
    • , Annika Hohm
    • , Lindsey A. Vandergrift
    • , Johannes Nowak
    • , Piet Habbel
    • , Igor A. Kaltashov
    •  & Leo L. Cheng
  • Review Article |

    Machine learning (ML) is revolutionizing and reshaping health care, and computer-based systems can be trained to perform complex tasks in bioinformatics, medical imaging and medical robotics. In this Review, Goldenberg et al. consider ML in the management of prostate cancer, with growing applications in diagnostic imaging, surgical interventions, skills training and assessment, digital pathology and genomics.

    • S. Larry Goldenberg
    • , Guy Nir
    •  & Septimiu E. Salcudean
  • Review Article |

    Many of the bacterial components of the female urinary tract have been characterized, but the viral fraction of this community is largely unknown. Here, the authors describe the current knowledge of bacteriophages within the urinary tract and their possible contribution to urinary tract health.

    • Andrea Garretto
    • , Taylor Miller-Ensminger
    • , Alan J. Wolfe
    •  & Catherine Putonti
  • News & Views |

    The PROSPER, SPARTAN, and ARAMIS trials demonstrated the efficacy of enzalutamide, apalutamide, and darolutamide, respectively, to extend metastasis-free survival in men with nonmetastatic castration-resistant prostate cancer. However, questions remain regarding patient selection for these agents, particularly concerning adverse effects, patient PSA doubling time, and cost and formulary considerations.

    • Celestia Higano
  • Consensus Statement | | open

    In this Consensus Statement, experts in the field detail the current evidence regarding blue light flexible cystoscopy for bladder cancer surveillance and make recommendations regarding its use on the basis of conclusions arrived at during the panel discussions at a consensus meeting.

    • Yair Lotan
    • , Trinity J. Bivalacqua
    • , Tracy Downs
    • , William Huang
    • , Jeffrey Jones
    • , Ashish M. Kamat
    • , Badrinath Konety
    • , Per-Uno Malmström
    • , James McKiernan
    • , Michael O’Donnell
    • , Sanjay Patel
    • , Kamal Pohar
    • , Matthew Resnick
    • , Alexander Sankin
    • , Angela Smith
    • , Gary Steinberg
    • , Edouard Trabulsi
    • , Michael Woods
    •  & Siamak Daneshmand
  • Perspective |

    Galectins have established roles in cancer, but their function in genitourinary cancer is unclear. In this Opinion, the authors discuss the emerging roles of galectins in prostate and bladder cancer development and progression and speculate regarding opportunities for clinical translation.

    • Neus Martínez-Bosch
    • , Alejo Rodriguez-Vida
    • , Núria Juanpere
    • , Josep Lloreta
    • , Ana Rovira
    • , Joan Albanell
    • , Joaquim Bellmunt
    •  & Pilar Navarro
  • Review Article |

    In this Review, the authors discuss biomarker-driven prostate cancer molecular subtyping and the development of nanodiagnostic strategies to refine biomarker detection. They also describe the challenges of merging both aspects for precision prostate cancer management.

    • Kevin M. Koo
    • , Paul N. Mainwaring
    • , Scott A. Tomlins
    •  & Matt Trau
  • News & Views |

    In the absence of standards of care and defined best treatments for localized prostate cancer, Internet search engines provide patients with first information — or often misinformation. Clinicians need to guide patients to sources of high-quality evidence on focal ablative treatments for prostate cancer.

    • Sangeet Ghai
    •  & John Trachtenberg
  • News & Views |

    The FDA’s approval of the first point-of-care total PSA test for prostate cancer has the potential to improve patient care by streamlining PSA testing. However, a Clinical Laboratory Improvement Amendments waiver is needed before this test can be fully integrated into clinical care.

    • Alexa R. Meyer
    •  & Michael A. Gorin
  • News & Views |

    Health-related quality of life encompasses a wide range of experiences and is especially relevant for men with prostate cancer. A recent study reports that across disease stages, overall self-reported health status and urinary and bowel function were good, but sexual function was poor. Overall, men face prostate cancer with resilience.

    • Mark S. Litwin
  • Review Article |

    Ambulatory urodynamic monitoring (AUM) offers numerous advantages over office-based urodynamics for evaluating urological conditions. This Review describes current trends and limitations of traditional urodynamics and advantages of AUM and highlights emerging telemetric AUM devices for bladder pressure and volume monitoring.

    • Benjamin Abelson
    • , Steve Majerus
    • , Daniel Sun
    • , Bradley C. Gill
    • , Eboo Versi
    •  & Margot S. Damaser
  • Review Article |

    The mesenchymal stem cell (MSC) secretome offers numerous advantages over cell-based therapy, with similar therapeutic effects. Here, the authors discuss the preclinical therapeutic promise of the MSC secretome in regenerative urology, highlighting putative mechanisms of action, characterization methods and future perspectives.

    • Daniel Z. Sun
    • , Benjamin Abelson
    • , Paurush Babbar
    •  & Margot S. Damaser
  • News & Views |

    Results of recent trials have shown the superiority of mpMRI to TRUS-guided systematic biopsy for detecting clinically significant prostate cancer. However, only performing an mpMRI risks missing MRI-invisible lesions and, therefore, there might be added value in performing both targeted and systematic biopsies in biopsy-naive patients.

    • Amir H. Lebastchi
    •  & Peter A. Pinto
  • Review Article |

    Macrophage migration inhibitory factor (MIF) can promote tumorigenesis by acting directly on cancer cells and by reversing immunosuppression. Advances have been made in our understanding of the role of MIF in the promotion of, and as a treatment target for, genitourinary cancers.

    • Justin C. Penticuff
    • , Benjamin L. Woolbright
    • , Thais M. Sielecki
    • , Scott J. Weir
    •  & John A. Taylor III
  • News & Views |

    In patients with metastatic renal cell carcinoma, risk stratification according to the Memorial Sloan Kettering Cancer Center or the International Metastatic Renal Cell Carcinoma Database Consortium classification systems is a crucial part of clinical assessment and essential for guiding management. New research has now demonstrated that disagreement in risk-group classification is common and prognostically relevant.

    • Tobias Klatte
    •  & Grant D. Stewart
  • News & Views |

    Continence in nursing home residents declines over time, probably owing to an increase in physical disability and impaired mobility as much as to lower urinary tract dysfunction. A need remains for appropriately skilled assessments of continence care, leading to multicomponent management of continence in this vulnerable group of patients.

    • Adrian Wagg
  • News & Views |

    Multiparametric MRI (mpMRI) has revolutionized prostate cancer diagnosis and risk stratification, but the question remains regarding what it is that we see (or don’t see) on mpMRI. A new study by Houlahan and colleagues now offers insight into the molecular characteristics of a tumour that influence mpMRI visibility.

    • Mark Emberton
  • Review Article |

    In the localized prostate cancer setting, germline BRCA2 mutations confer aggressive clinicopathological features and poor outcomes. This Review discusses the clinical influence of BRCA2 mutations in localized disease, highlighting biological insights into disease aggressiveness from genomic studies and preclinical models.

    • Renea A. Taylor
    • , Michael Fraser
    • , Richard J. Rebello
    • , Paul C. Boutros
    • , Declan G. Murphy
    • , Robert G. Bristow
    •  & Gail P. Risbridger
  • News & Views |

    Reassurance provided by pre-exposure prophylaxis (PrEP) for HIV might lead to increased sexual risk-taking in men who have sex with men (MSM), potentially increasing the risk of transmitting other infections. A recent study has shown increased transmission of hepatitis C virus (HCV) in this population, suggesting a need for HCV screening.

    • Douglas S. Krakower
    •  & Kenneth H. Mayer
  • Editorial |

    Understanding the disparities between a surgeon and patient experience is valuable for both. And what patient is better placed to describe their prostate cancer journey than Stephen Fry?

  • Viewpoint |

    In this Viewpoint, actor, author, and broadcaster Stephen Fry describes his prostate cancer journey alongside the same story from his surgeon, Ben Challacombe, enabling us to consider “both sides of the scalpel”.

    • Stephen Fry
    •  & Ben Challacombe
  • News & Views |

    The use of optogenetic strategies in biomedicine therapeutics has the potential to provide nonpharmacological modulation of nervous system function. The development of integrative, implantable, remote-powered devices is an advance towards translation of these strategies, with the potential for precision, revolutionary treatment of complex or refractory disease-related or trauma-related symptoms.

    • Warren M. Grill
    •  & Jennifer J. DeBerry