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  • MRI and the Vesical Imaging-Reporting And Data System are highly accurate imaging tools for bladder cancer staging. A panel of experts have agreed on their efficacy in different clinical settings for cancer care, using the Delphi methodology. This Expert Recommendation will provide guidance for future research agendas.

    • Valeria Panebianco
    • Alberto Briganti
    • J. Alfred Witjes
    Expert Recommendation
  • Artificial intelligence (AI) has the potential to revolutionize scientific publishing. The influence of AI could be disruptive or destructive and its influence remains to be seen, but balance between the convenience and accessibility offered by AI-driven tools and the essential skills of deep scientific inquiry and communication needs to be found.

    • Riccardo Bertolo
    • Alessandro Antonelli
  • The escalating global prevalence of urinary stone disease and its impact on public health reflects the need to synthesize ideas that can help with the development of critical research priorities. By bringing together a forum of endourologists with the support of a funding agency, the IDEA session aimed to identify important future research topics.

    • Golena Fernandez Moncaleano
    • William W. Roberts
    • Khurshid R. Ghani
  • Genetic and ancestral factors, molecular pathways involving androgen and non-androgen receptor signalling, inflammation, epigenetics, the tumour microenvironment and tumour metabolism are posited as biological factors that potentially contribute to racial disparities in Black men with prostate cancer.

    • Jun Gong
    • Daniel M. Kim
    • Stephen J. Freedland
    Review Article
  • Sexual interactions between members of the same sex are common but the reasons for these behaviours are not always clear. Results from a study across mammals suggest that increased same-sex behaviour evolved with sociality and might reduce conflict, although increased male–male sexual interactions are associated with increased adult killing.

    • C. Ruth Archer
    • David J. Hosken
    News & Views
  • Senescent stromal fibroblasts exhibit a senescence-associated secretory phenotype, which can promote prostate cancer development, progression and resistance to therapy. Targeting senescent cells via senotherapeutics might be an attractive preventive or therapeutic option for prostate cancer.

    • Joakin O. Mori
    • Isra Elhussin
    • Christopher M. Heaphy
    Review Article
  • Here, the authors describe the history of the efforts to expand knowledge of Wilms tumour biology, genetics, embryonal origin and associated syndromic and familial conditions, and to clinically apply prognostic biomarkers and development of preclinical models.

    • Daniela Perotti
    • Richard D. Williams
    • Kathy Pritchard-Jones
    Review Article
  • In this Expert Recommendation, the most pressing questions related to male reproductive health, spanning the spectrum of andrology, are identified. These questions encompass and highlight many opportunities to influence the wellness of future generations.

    • Sarah Kimmins
    • Richard A. Anderson
    • Moira K. O’Bryan
    Expert Recommendation
  • Much of the Y chromosome has remained obscure owing to the challenge of sequencing repetitive genomic regions. Recently, the Y chromosome has been fully sequenced, revealing extensive heterochromatic areas and 41 new protein-coding genes. Furthermore, 43 Y chromosomes have been sequenced, showing extensive multi-sample variation and providing promising insights into male infertility.

    • Miguel G. Rojas
    • Edoardo Pozzi
    • Ranjith Ramasamy
    News & Views
  • In this Review, the authors provide an overview of currently available diagnostic liquid biopsy biomarkers for renal cell carcinoma, comparing clinical potential and limitations of the three most promising liquid biomarkers: circulating tumour cells, extracellular vesicles and cell-free DNA.

    • Richard C. Zieren
    • Patricia J. Zondervan
    • Adriaan D. Bins
    Review Article
  • In this Expert Recommendation, the authors provide a standardized nomenclature to improve the Human Phenotype Ontology tree with regard to the classification of non-syndromic male infertility. The implications of introducing this vocabulary in promoting communication across disciplines and institutions and in discovering novel genetic causes of non-syndromic male infertility are also discussed.

    • Margot J. Wyrwoll
    • Godfried W. van der Heijden
    • Frank Tüttelmann
    Expert Recommendation
  • Rare male sexual disorders — including post-finasteride syndrome, restless genital syndrome, post-orgasmic illness syndrome, post-SSRI sexual dysfunction, hard–flaccid syndrome, sleep-related painful erections and post-retinoid sexual dysfunction — are under-recognized and under-treated, leading to considerable morbidity, with adverse effects on individuals’ sexual health and relationships. The literature surrounding such disorders is scarce and their aetiology has not been fully elucidated. In this Review, the authors discuss possible aetiologies of these disorders, as well as the need for clinician awareness and large-scale studies to better understand how to best serve patients.

    • Murat Gül
    • Mikkel Fode
    • Ege Can Serefoglu
    Review Article
  • Positive surgical margins are an independent risk factor for biochemical recurrence after radical prostatectomy. However, the identification of residual cancer by eye is highly limited, and frozen sections are not always available or possible for all margins. Prostate-specific membrane antigen-targeted fluorescence guidance might close this gap and enhance the surgeon’s eye.

    • Fabian Falkenbach
    • Tobias Maurer
    News & Views