Bladder with immune cells and microbes

Bladder cancer, inflammageing and microbiomes

The complex links among ageing, inflammation and dysbiosis in the pathology of bladder cancer.

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    • Several studies over the past few decades have suggested that sperm quality varies by geographical region and might be subject to a temporal decline worldwide. However, the data supporting these conclusions have come from studies of various methodologies and heterogeneous populations, making them unreliable. In this in-depth Review, Chevrier and colleagues discuss the data surrounding discussion of spatiotemporal trends in semen parameters and consider how these trends and the factors promoting them interact.

      • Jacques Auger
      • Florence Eustache
      • Bernard Jégou
      Review Article
    • Diabetic bladder dysfunction (DBD) is a common complication of diabetes. Hyperglycaemia-induced oxidative stress is thought to mediate functional changes in organs and tissues affected by DBD. In this Review, the authors provide an overview of mechanisms and consequences of oxidative stress, focusing on the role of diabetes-induced oxidative stress in generating dysfunctions at the level of the urothelium, smooth muscle contractility and nerve structures involved in DBD pathogenesis.

      • Qi-Xiang Song
      • Yi Sun
      • Margot S. Damaser
      Review Article
    • In this Review, the authors discuss racial differences in the prevalence of genetic mutations in the main molecular drivers of prostate cancer and provide input regarding the role of genomics in racial disparities observed in prostate cancer outcomes.

      • Camilo Arenas-Gallo
      • Jude Owiredu
      • Jonathan E. Shoag
      Perspective
    • Muscle-invasive bladder cancer (MIBC) remains a deadly disease, despite aggressive surgical and systemic chemotherapeutic treatments. New treatment modalities are needed. A novel intravesicle drug delivery device for neoadjuvant treatment of MIBC has been developed, and preliminary results on the efficacy and safety of this system are available.

      • Katherine M. Rodriguez
      • Max Kates
      News & Views