Sexual interactions between members of the same sex are common but the reasons for these behaviours are not always clear. Results from a study across mammals suggest that increased same-sex behaviour evolved with sociality and might reduce conflict, although increased male–male sexual interactions are associated with increased adult killing.

Senescent stromal fibroblasts exhibit a senescence-associated secretory phenotype, which can promote prostate cancer development, progression and resistance to therapy. Targeting senescent cells via senotherapeutics might be an attractive preventive or therapeutic option for prostate cancer.

Here, the authors describe the history of the efforts to expand knowledge of Wilms tumour biology, genetics, embryonal origin and associated syndromic and familial conditions, and to clinically apply prognostic biomarkers and development of preclinical models.

In this Expert Recommendation, the most pressing questions related to male reproductive health, spanning the spectrum of andrology, are identified. These questions encompass and highlight many opportunities to influence the wellness of future generations.