PIONEER is a European network of excellence for big data in prostate cancer, which brings together private and public stakeholders from nine countries in one multidisciplinary research consortium. In this Perspectives, members of the consortium detail the achievements of PIONEER and describe its goal of maximizing the potential of big data to improve prostate cancer care in the future.

In this Perspective, the authors provide an overview of the most promising deregulated non-coding RNAs in clear-cell renal cell carcinoma, discussing the role of different classes of non-coding RNAs in clear-cell renal cell carcinoma development and progression. Future perspectives and challenges associated with the translation of these markers into clinical practice are also discussed.

In this Review, the authors provide a comprehensive overview of videourodynamics, discussing terminology, technique, findings, limitations and future perspectives associated with this approach.

This Review focusses on what is known about the interactions between conventional radiotherapy and the immune system. The authors discuss how this knowledge can be applied to investigate gaps regarding the immune interactions of molecular radiotherapies.