Nonantibiotic prevention and management of recurrent urinary tract infection

The need for nonantibiotic treatments for the prevention and management of recurrent UTI are discussed in this article.

Latest Reviews

  • Review Article |

    This Review discusses the challenges in accurately identifying rare prostate circulating tumour cells or bone marrow-derived disseminated tumour cells and the resulting need for prostate-specific, sensitive biomarkers for the detection of these cells in liquid biopsy samples.

    • Emma E. van der Toom
    • , Haley D. Axelrod
    • , Jean J. de la Rosette
    • , Theo M. de Reijke
    • , Kenneth J. Pienta
    •  & Kenneth C. Valkenburg
  • Review Article |

    In this Review, the authors describe the current mechanistic understanding of infection stone formation and growth, including the influence of the organic matrix, microorganisms, and biofilms, highlighting the medical implications of these insights and the importance of multidisciplinary management approaches.

    • Erika J. Espinosa-Ortiz
    • , Brian H. Eisner
    • , Dirk Lange
    •  & Robin Gerlach
  • Review Article |

    Urinary extravasation occurs in ~30% of patients with high-grade renal trauma, but the lack of evidence-based guidelines complicates its clinical management. Here, the authors discuss the diagnosis and management of urinary extravasation, highlighting important knowledge gaps and future research directions.

    • Sorena Keihani
    • , Ross E. Anderson
    • , James M. Hotaling
    •  & Jeremy B. Myers
  • Review Article |

    Nonoperative management is the only treatment option for Peyronie’s disease in the acute phase of the disease, when surgery is contraindicated. In this Review, Tsambarlis and Levine discuss the oral and topical therapies that have been shown to be efficacious and provide recommendations for their use.

    • Peter Tsambarlis
    •  & Laurence A. Levine
  • Review Article |

    The penis is a diverse and rapidly evolving structure, much more complex than its fundamental function — sperm transfer — would seem to require. In this Review, experts in the field discuss the drivers of penis evolution, and consider how the penis might be an ideal characteristic on which to focus in studies to link phenotype with genotype.

    • David J. Hosken
    • , C. Ruth Archer
    • , Clarissa M. House
    •  & Nina Wedell
  • Review Article |

    Transgender persons can be affected by sexual dysfunctions before, during, after, because of, and despite therapy. In this Review, experts in the field discuss trans sexuality across the gender dysphoric spectrum, and suggest ways in which trans persons can be supported in their sexuality and sexual function.

    • Mats Holmberg
    • , Stefan Arver
    •  & Cecilia Dhejne

News & Comment

  • Comment |

    Despite initial enthusiasm, poor translation of preclinical studies and high-profile scandals involving stem cell research have hindered the field of regenerative urology in recent years. However, consideration of the potential of regenerative approaches to revolutionize patient care ought to reignite interest and begin a renaissance in regenerative urology research.

    • Margot S. Damaser
    •  & Karl-Dietrich Sievert
  • Year in Review |

    2018 has been an exciting year for imaging in urology, especially in the field of prostate cancer. In this context, multiparametric MRI and molecular imaging targeting prostate-specific membrane antigen provide practice-changing developments for detection and diagnostic work-up.

    • Tobias Maurer
    •  & Matthias Eiber
  • Year in Review |

    The treatment of metastatic kidney cancer is rapidly evolving with the shift from immune checkpoint inhibitor monotherapy to combination therapy. In 2018, the combination of nivolumab–ipilimumab received regulatory approval and multiple positive clinical trials were reported with combinations of PD-1 or PD-L1 inhibitors in conjunction with antiangiogenic drugs.

    • Chung-Han Lee
    •  & Robert J. Motzer
  • News & Views |

    The extent of pelvic lymph node dissection at the time of radical cystectomy is debated as it might affect oncological outcomes in patients with bladder cancer. Gschwend et al. now demonstrate that the survival benefit is small and that the study might need to be repeated with a larger cohort.

    • Fiona C. Burkhard
    •  & George N. Thalmann