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Neutrophil extracellular trap proteins trigger an accelerated form of osteoclastogenesis that is enhanced by the presence of carbamylated proteins and is linked to bone erosion.
Analyses of data from the Danish national patient register show that diabetes mellitus increases the risk of end-stage renal disease in patients with systemic lupus erythematosus.
A newly developed nanobody that simultaneously targets TNF and IL-6 has greater efficacy than individual targeting in rheumatoid arthritis disease-relevant preclinical models.
A new study identifies proteinase 3 as an important driver of granuloma formation in granulomatosis with polyangiitis and points to potential therapeutic approaches.
A panel of serum biomarkers identified by proteomic analysis outperforms the best current alternatives for prediction of the progression of osteoarthritis.
Autoantibodies against rheumatoid arthritis (RA)-related peptides present in joints can be detected in the serum of patients with early RA using a multiplex immunoassay.
Results indicate that prophylactic use of co-trimoxazole can reduce infection-related mortality in patients with new-onset anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis.
Protein phosphatase magnesium-dependent 1A is a negative modulator of transforming growth factor β signalling and a potential new therapeutic target in osteoarthritis.
Expression of the Na+-K+-ATPase transmembrane ion transporter is upregulated in kidney-infiltrating B cells in lupus-prone mice and is a potential target for reducing renal B cell survival in patients with lupus nephritis.
Allogeneic transplantation of cartilage organoids derived from induced pluripotent stem cells promoted cartilage repair in a primate model without eliciting immune reactions.
An ambitious project to update the classification of vasculitis syndromes has culminated in the development of new classification criteria for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, Takayasu arteritis and giant cell arteritis. Endorsed by the ACR and EULAR, the new criteria reflect progress in the understanding and assessment of these conditions.
In this Review, the authors describe the relationships between persistent DNA damage, inflammation and cellular senescence, which represent a common pathway that contributes to the pathology of many conditions, including rheumatic diseases.
Pope et al. review the current management (including both screening and treatment) of organ-based manifestations of systemic sclerosis as well as overall disease modification, with a focus on evidence from clinical trials and consensus recommendations.
In systemic lupus erythematosus, renal involvement is known as lupus nephritis and it is associated with mortality and morbidity. This Review compares and contrasts the existing management guidelines for lupus nephritis and describes emerging therapeutic approaches and the feasibility of precision medicine.
Sarcopenia, which involves the generalized loss of skeletal muscle strength and mass, is commonly associated with rheumatoid arthritis. In this Review, the authors discuss the epidemiology, pathophysiology and identification of rheumatoid sarcopenia and present evidence for the therapeutic roles of physical activity, nutrition and pharmacotherapy.
