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The IL-17A–IL-17F inhibitor bimekizumab is safe and effective for the treatment of both radiographic and non-radiographic axial spondyloarthritis, according to the results of two parallel phase III trials.
Age-related stiffening of the extracellular matrix in cartilage promotes chondrocyte ageing in an epigenetically controlled process involving repression of the longevity protein α-Klotho.
IKKε, an upstream regulator of the NF-κB signalling pathway, mediates cartilage degradation in a mouse model of osteoarthritis and is a potential therapeutic target.
New research suggests that impaired synovial lymphatic function contributes to the pathogenesis of age-related osteoarthritis and could represent a new therapeutic target.
Blockade of iron uptake by the transferrin receptor CD71 can reduce metabolic dysregulation in T cells, resulting in amelioration of autoimmune pathology in lupus-prone mice.
IL-37 can delay intervertebral disc degeneration in rats by regulating the NF-κB pathway and ameliorating the senescence phenotype of nucleus pulposus cells.
The phenotypic and functional heterogeneity of synovial tissue fibroblasts are well described, whereas the cellular and molecular mechanisms that establish this diverse fibroblast repertoire in the adult joint have remained unclear. When is the fate of synovial fibroblast repertoire determined, and what are the consequences for arthritis development as adults?
The mechanisms underlying the genetic association between HLA-B27 and ankylosing spondylitis, including the contribution of endoplasmic reticulum aminopeptidase 1 (ERAP1), continue to elude the field. New findings support the involvement of the unfolded protein response and highlight the therapeutic potential and limitations of targeting ERAP1 in this disease.
In this Review, the authors discuss the similarities and differences between intervertebral disc degeneration and osteoarthritis of the facet joint and argue that both diseases should be viewed as being part of the same molecular disease spectrum.
In this Review, the authors discuss how emerging insights into the tissue-specific pathogenetic mechanisms underlying clinical heterogeneity in psoriatic arthritis support the need for tissue-based precision therapy for the disease.
Gastrointestinal dysmotility is a major complication of systemic sclerosis but remains poorly understood. In this Review, the authors discuss the current understanding of systemic sclerosis gastrointestinal disease, existing and emerging therapies, and promising directions for future research
Next-generation sequencing has led to the discovery of multiple rare autoinflammatory diseases, together with their corresponding disease-causing mutations, creating opportunities to develop personalized medicine and providing useful insight into more common forms of autoimmunity and autoinflammation.
