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New research suggests that the transcription factor ETS1 expressed in fibroblasts regulates the tissue-destructive properties of these cells in multiple diseases, and could offer a novel therapeutic strategy.
New research in a mouse model of osteoarthritis shows that the RNA-binding protein Lin28a is expressed in chondrocytes and limits cartilage damage by inhibition of Let-7 microRNAs.
Members of the Temporomandibular Joint Juvenile Arthritis Working group (TMJaw) provide a set of interdisciplinary recommendations for the management of TMJ arthritis.
A new study has identified an association of Thy-1 expression with skin fibrosis in systemic sclerosis, and has shown that Thy1 knockout in mice attenuates bleomycin-induced skin fibrosis.
New research suggests that the pro-inflammatory effects of TNF on rheumatoid arthritis synovial fibroblasts are mediated by extracellular sulfatase Sulf2, which could present a novel target for treatment.
Results from two parallel trials suggest that withholding methotrexate only after the second dose of a COVID vaccine is safe and effective in patients with rheumatoid arthritis or psoriatic arthritis.
Transitional care in rheumatology has been debated for over three decades and yet unmet needs of young people are still being reported. Why the slow progress? Perhaps we need to stop talking about transitional care in rheumatology and talk more about developmentally appropriate health care for young people with rheumatic conditions.
New research shows that TNF can directly induce osteoclastogenesis from transforming growth factor-β (TGFβ)-primed macrophages and that knockout of TGFβ signalling limits TNF-induced arthritic bone erosion in mice, suggesting that TGFβ inhibition could enhance the effect of anti-TNF therapy in rheumatoid arthritis.
Often viewed as merely an inconsequential episode of acute joint pain, gout flare has also been associated with an increased risk of acute myocardial infarction and stroke. New findings suggest the risk is highest within the first 60 days of gout flare, and could be influenced by flare treatment.
The mitochondrion has multiple functions, including energy production, regulation of apoptosis and reactive oxygen species generation. Disruption of these mitochondrial processes can lead to pro-inflammatory immune responses. This Review discussions the role of mitochondria and mitochondrial dysfunction in rheumatic diseases.
In this Review, the authors discuss the use of immune-checkpoint inhibitors for treatment of cancer in patients with pre-existing autoimmune disease, including the possibility of the use of biologic DMARDs to enhance tumour responses while preventing severe immune-related adverse events.
In this Review, the authors discuss the roles of sex and gender in relation to axial spondyloarthritis. Although evidence now suggests that the disease has equal prevalence in men and women, important differences occur in phenotypes, response to therapy and outcomes.