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Volume 18 Issue 11, November 2022

COVER: Inspired by the Review on p621.

Cover design: Alex Whitworth

Research Highlights

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News & Views

  • Transitional care in rheumatology has been debated for over three decades and yet unmet needs of young people are still being reported. Why the slow progress? Perhaps we need to stop talking about transitional care in rheumatology and talk more about developmentally appropriate health care for young people with rheumatic conditions.

    • Janet E. McDonagh
    • Albert Farre
    News & Views
  • New research shows that TNF can directly induce osteoclastogenesis from transforming growth factor-β (TGFβ)-primed macrophages and that knockout of TGFβ signalling limits TNF-induced arthritic bone erosion in mice, suggesting that TGFβ inhibition could enhance the effect of anti-TNF therapy in rheumatoid arthritis.

    • Zhenqiang Yao
    • Brendan F. Boyce
    News & Views
  • Often viewed as merely an inconsequential episode of acute joint pain, gout flare has also been associated with an increased risk of acute myocardial infarction and stroke. New findings suggest the risk is highest within the first 60 days of gout flare, and could be influenced by flare treatment.

    • Hyon K. Choi
    • Natalie McCormick
    News & Views
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Reviews

  • The mitochondrion has multiple functions, including energy production, regulation of apoptosis and reactive oxygen species generation. Disruption of these mitochondrial processes can lead to pro-inflammatory immune responses. This Review discussions the role of mitochondria and mitochondrial dysfunction in rheumatic diseases.

    • Yann L. C. Becker
    • Bhargavi Duvvuri
    • Eric Boilard
    Review Article
  • In this Review, the authors discuss the roles of sex and gender in relation to axial spondyloarthritis. Although evidence now suggests that the disease has equal prevalence in men and women, important differences occur in phenotypes, response to therapy and outcomes.

    • Rachael Stovall
    • Irene E. van der Horst-Bruinsma
    • Lianne S. Gensler
    Review Article
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