Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 17 Issue 5, May 2021

Inspired by the Review on p257.

Cover design: S.Harris/Springer Nature Limited


  • The Human Cell Atlas (HCA) project aims to map tissues and organs during development, maturation and pathology at single cell resolution. The musculoskeletal HCA network is a community for fostering collaboration and shared expertise to help develop the therapeutic approaches needed to address the high global burden of musculoskeletal disorders.

    • Mathew J. Baldwin
    • Adam P. Cribbs
    • Sarah J. B. Snelling


Top of page ⤴

Research Highlights

Top of page ⤴

News & Views

  • A multitude of factors contribute to the development and progression of systemic lupus erythematosus (SLE) through their effects on immune cells and tissue resident cells. Ultraviolet light instigates skin inflammation in SLE, and now new findings suggest that neutrophils in the inflamed skin migrate to the kidneys, spreading the inflammatory response.

    • Antonios G. A. Kolios
    • George C. Tsokos
    News & Views
  • Myositis is a group of conditions that vary greatly in risk factors, clinical manifestations, laboratory markers, presumed pathogenetic mechanisms, treatment responses and prognoses. Approaches to divide myositis into mutually exclusive and stable phenotypes are being considered, but are we thinking comprehensively enough in our attempts at classification?

    • Frederick W. Miller
    News & Views
Top of page ⤴


  • Childhood-onset arthritis has historically been treated as a separate entity to adult-onset arthritis, with its own nomenclature and classification system. Biological evidence has revealed the limitations of the current approach, necessitating a fresh look at the classification of paediatric arthritis.

    • Peter A. Nigrovic
    • Robert A. Colbert
    • Alberto Martini
    Review Article
  • Various drugs used in rheumatoid arthritis management have anti-inflammatory effects that can hinder atherosclerosis development and progression. However, these drugs can also concurrently have different pro-atherogenic effects, complicating the relationship between these drugs and cardiovascular involvement in rheumatoid arthritis.

    • Fabiola Atzeni
    • Javier Rodríguez-Carrio
    • Zoltán Szekanecz
    Review Article
  • Pathogenic, long-lived memory cells of the immune system present a barrier to resolution of chronic inflammatory rheumatic diseases. Approaches to selectively eliminate these cells while sparing protective immune memory cells could restore immunological tolerance and achieve treatment-free remission.

    • Patrick Maschmeyer
    • Hyun-Dong Chang
    • Andreas Radbruch
    Review Article
Top of page ⤴

Amendments & Corrections

Top of page ⤴


Quick links