The changing prevalence of the risk factors for gout, which include genetic factors, excess alcohol consumption, purine-rich diet, the metabolic syndrome, diuretic use, and osteoarthritis, are influencing the prevalence and clinical presentation of this common crystal deposition disorder. In addition, as is discussed in this Review, suboptimum management is contributing to the rise in the prevalence of clinically significant symptomatic chronic gout.
- Edward Roddy
- Weiya Zhang
- Michael Doherty