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This Focus issue on osteoarthritis includes a series of specially commissioned Reviews from leading researchers in the field looking at disease pathogenesis in terms of cytokines, subchondral bone, cartilage matrix, and muscle strength and proprioception, with the hope of clarifying what the key processes are; in addition, Reviews focusing on the prospects for disease-modifying therapies for osteoarthritis, and on the genetic epidemiology of this disease are included.
This Focus issue on systemic lupus erythematosus (SLE) contains specially commissioned Reviews and Perspectives articles that aim to translate the latest insights into the pathogenesis and management of SLE into clinical practice, including advances in knowledge of the genetics and immunopathogenesis of SLE and the implications of these innovations for current and emerging treatments.
With the aim of highlighting the challenges faced by rheumatologists, articles in this Focus issue of Nature Reviews Rheumatologydiscuss pharmacological and nonpharmacological therapies and how best to integrate these to achieve effective pain-relief for patients with chronic musculoskeletal diseases.
This Focus issue on the future of therapy for rheumatoid arthritis (RA) contains a specially commissioned lead Review on the current state-of-the-art therapeutic approaches for RA and a series of shorter Review articles that introduce some new molecules and cells identified by the leaders in this field as the next promising targets for this disease.