Research Highlights

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  • A gut bacterium found in people at risk of rheumatoid arthritis (RA) or with early RA is recognized by circulating autoantibodies, and is arthritogenic when it colonizes germ-free mice, suggesting a causal role in RA development.

    • Robert Phillips
    Research Highlight
  • New research demonstrates that unrestrained cutaneous growth of Staphylococcus aureus causes autoimmunity characteristic of systemic lupus erythematosus in mice.

    • Robert Phillips
    Research Highlight
  • Using a combination of various single-cell and immune profiling approaches, researchers have characterized the unique adaptive immune landscape of anti-melanoma differentiation-associated gene 5 antibody-positive (MDA5+) dermatomyositis.

    • Jessica McHugh
    Research Highlight
  • New research suggests therapies targeting neutrophil activation pathways could protect against arterial and venous thrombosis.

    • Sarah Onuora
    Research Highlight
  • Results from a study of CAR T cell therapy in five patients with treatment-refractory systemic lupus erythematosus demonstrate the induction of sustained drug-free disease remission.

    • Robert Phillips
    Research Highlight
  • A new study has identified an association of Thy-1 expression with skin fibrosis in systemic sclerosis, and has shown that Thy1 knockout in mice attenuates bleomycin-induced skin fibrosis.

    • Robert Phillips
    Research Highlight
  • Results from two parallel trials suggest that withholding methotrexate only after the second dose of a COVID vaccine is safe and effective in patients with rheumatoid arthritis or psoriatic arthritis.

    • Jessica McHugh
    Research Highlight
  • New research in a mouse model of osteoarthritis shows that the RNA-binding protein Lin28a is expressed in chondrocytes and limits cartilage damage by inhibition of Let-7 microRNAs.

    • Robert Phillips
    Research Highlight
  • New research suggests that the pro-inflammatory effects of TNF on rheumatoid arthritis synovial fibroblasts are mediated by extracellular sulfatase Sulf2, which could present a novel target for treatment.

    • Sarah Onuora
    Research Highlight
  • A short questionnaire designed for use by dermatologists to screen patients with psoriasis can be used for the selection of individuals for MRI assessment of axial psoriatic arthritis.

    • Robert Phillips
    Research Highlight
  • New research sheds light on how disruption of peripheral circadian rhythms mediates inflammation-induced intervertebral disc degeneration and suggests a therapeutic approach to target these mechanisms.

    • Sarah Onuora
    Research Highlight