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New findings suggest that neutrophil extracellular traps and their components have a functional role as triggers of IL-17-mediated inflammation and associated bone destruction in periodontitis.
Researchers have co-cultured human mesenchymal stromal cells and monocytes to generate bone-like structures that have the potential to facilitate the study of bone remodelling in vitro.
The ACR has developed its first guideline for managing rheumatoid arthritis using integrative interventions, to aid in decision-making regarding such approaches alongside pharmacological treatment.
New research demonstrates that regulatory T cells in gut and joint tissues differ in their response to and ability to control TNF-mediated inflammation.
Cognitive functional therapy is a safe, effective and low-cost intervention for individuals with persistent disabling low back pain, according to results from the phase III RESTORE trial.
Results of a population-based cohort study of more than 20 million individuals in the UK reveal that the incidence of several autoimmune disorders, and of rheumatic diseases in particular, continues to increase over time.
Magnesium ascorbyl phosphate is a stable derivative of ascorbic acid that has now been shown to promote bone formation via stimulation of the CAMKIIα pathway.
A new treatment for osteoarthritis that combines cells from the patient in vitro prior to intra-articular injection has demonstrated beneficial effects on arthritic joints in a compassionate use study.
In a retrospective study, risk–benefit analyses suggest that primary prophylaxis against Pneumocystis jirovecii pneumonia is beneficial in patients receiving rituximab and high-dose glucocorticoids.
In a retrospective study, biologic DMARD therapy was associated with faster control of immune checkpoint inhibitor-associated arthritis but also with a shorter time to cancer progression, compared with methotrexate therapy.
Clinical and molecular analysis of autoantibodies against the endonuclease DNase1L3 in patients with systemic lupus erythematosus led to the identification of a subset of pathogenetic antibodies that are cross-reactive with double-stranded DNA.
In screening for post-translational modifications associated with ankylosing spondylitis, researchers have identified a microbiome-metabolite-mediated modification that can lead to neoantigen generation and subsequent autoimmunity.
Characterization of a new mouse model highlights allogeneic bone marrow transplantation and granulocyte colony-stimulating factor neutralization as potential avenues for the treatment of APLAID.
New findings suggest that inhibition of macrophage fumarate hydratase leads to the release of mitochondrial RNA, which in turn mediates type I interferon production.
Following a fracture, γδ T cell expansion in the bone induces the expansion and migration of T helper 17 cells from the gut to the bone to help mediate fracture healing.
Anti-citrullinated protein antibodies precede the development of rheumatoid arthritis, but new results indicate that these antibodies are not necessarily pathogenic, and some might even protect against arthritis.
A comprehensive analysis has identified chromatin looping as the mechanism that underlies the association of a pleiotropic genetic variant with several autoimmune diseases.
