Research Highlights

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  • Results from a study of CAR T cell therapy in five patients with treatment-refractory systemic lupus erythematosus demonstrate the induction of sustained drug-free disease remission.

    • Robert Phillips
    Research Highlight
  • A new study has identified an association of Thy-1 expression with skin fibrosis in systemic sclerosis, and has shown that Thy1 knockout in mice attenuates bleomycin-induced skin fibrosis.

    • Robert Phillips
    Research Highlight
  • Results from two parallel trials suggest that withholding methotrexate only after the second dose of a COVID vaccine is safe and effective in patients with rheumatoid arthritis or psoriatic arthritis.

    • Jessica McHugh
    Research Highlight
  • New research in a mouse model of osteoarthritis shows that the RNA-binding protein Lin28a is expressed in chondrocytes and limits cartilage damage by inhibition of Let-7 microRNAs.

    • Robert Phillips
    Research Highlight
  • New research suggests that the pro-inflammatory effects of TNF on rheumatoid arthritis synovial fibroblasts are mediated by extracellular sulfatase Sulf2, which could present a novel target for treatment.

    • Sarah Onuora
    Research Highlight
  • A short questionnaire designed for use by dermatologists to screen patients with psoriasis can be used for the selection of individuals for MRI assessment of axial psoriatic arthritis.

    • Robert Phillips
    Research Highlight
  • New research sheds light on how disruption of peripheral circadian rhythms mediates inflammation-induced intervertebral disc degeneration and suggests a therapeutic approach to target these mechanisms.

    • Sarah Onuora
    Research Highlight
  • New research attempts to explore the cause of plasmacytoid dendritic cell hyperactivation in systemic lupus erythematosus by focusing on genetic risk variation.

    • Jessica McHugh
    Research Highlight
  • The findings of a new study suggest that the adipokine FABP4 promotes multiple pathological changes in rheumatoid arthritis and could represent a new therapeutic target.

    • Sarah Onuora
    Research Highlight
  • A new study uncovers a protective role for epidermal S100A9 in psoriasis and psoriatic arthritis, and highlights this alarmin as a potential biomarker of disease progression.

    • Jessica McHugh
    Research Highlight
  • New research shows that annexin A1 has a protective role in periprosthetic osteolysis and could offer a therapeutic approach to this common cause of arthroplasty failure.

    • Sarah Onuora
    Research Highlight
  • By isolating CD4+ T cells from patients with primary Sjögren syndrome, a new study has identified the involvement of a targetable interferon signalling pathway in T cell differentiation and B cell activation.

    • Robert Phillips
    Research Highlight