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Results from a study of CAR T cell therapy in five patients with treatment-refractory systemic lupus erythematosus demonstrate the induction of sustained drug-free disease remission.
New research suggests that the transcription factor ETS1 expressed in fibroblasts regulates the tissue-destructive properties of these cells in multiple diseases, and could offer a novel therapeutic strategy.
Members of the Temporomandibular Joint Juvenile Arthritis Working group (TMJaw) provide a set of interdisciplinary recommendations for the management of TMJ arthritis.
A new study has identified an association of Thy-1 expression with skin fibrosis in systemic sclerosis, and has shown that Thy1 knockout in mice attenuates bleomycin-induced skin fibrosis.
Results from two parallel trials suggest that withholding methotrexate only after the second dose of a COVID vaccine is safe and effective in patients with rheumatoid arthritis or psoriatic arthritis.
New research in a mouse model of osteoarthritis shows that the RNA-binding protein Lin28a is expressed in chondrocytes and limits cartilage damage by inhibition of Let-7 microRNAs.
New research suggests that the pro-inflammatory effects of TNF on rheumatoid arthritis synovial fibroblasts are mediated by extracellular sulfatase Sulf2, which could present a novel target for treatment.
A short questionnaire designed for use by dermatologists to screen patients with psoriasis can be used for the selection of individuals for MRI assessment of axial psoriatic arthritis.
New research sheds light on how disruption of peripheral circadian rhythms mediates inflammation-induced intervertebral disc degeneration and suggests a therapeutic approach to target these mechanisms.
The newly developed Z583 is a potent and highly specific inhibitor of JAK3, with a favourable in vitro and in vivo safety profile and effectiveness in treatment of collagen-induced arthritis in mice.
A new study reveals a non-canonical function for the histone demethylase JMJD1C that restrains plasma cell differentiation and protects mice from experimental arthritis.
New findings support the existence of an antigen presentation-independent mechanism known as the ‘cusp theory’ and the involvement of a newly discovered ‘lupus epitope’ in systemic lupus erythematosus susceptibility.
New research attempts to explore the cause of plasmacytoid dendritic cell hyperactivation in systemic lupus erythematosus by focusing on genetic risk variation.
The findings of a new study suggest that the adipokine FABP4 promotes multiple pathological changes in rheumatoid arthritis and could represent a new therapeutic target.
Three new reports of results from two clinical trials of bimekizumab indicate that it is safe and efficacious for the long-term treatment of patients with ankylosing spondylitis or psoriatic arthritis.
A new study uncovers a protective role for epidermal S100A9 in psoriasis and psoriatic arthritis, and highlights this alarmin as a potential biomarker of disease progression.
New research shows that annexin A1 has a protective role in periprosthetic osteolysis and could offer a therapeutic approach to this common cause of arthroplasty failure.
New research shows that one of the two main isoforms of the human FOXP3 transcription factor is associated with inflammatory transcriptional regulation and autoimmunity.
New results have identified a targetable pathway involved in invasiveness and resistance to detachment-mediated apoptosis in rheumatoid arthritis synovial fibroblasts.
By isolating CD4+ T cells from patients with primary Sjögren syndrome, a new study has identified the involvement of a targetable interferon signalling pathway in T cell differentiation and B cell activation.
