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In a large cohort of patients with psoriasis, treatment with biologic DMARDs targeting the IL-23 pathway was associated with a reduced risk of developing inflammatory arthritis as compared with anti-TNF treatment.
Protein phosphatase magnesium-dependent 1A is a negative modulator of transforming growth factor β signalling and a potential new therapeutic target in osteoarthritis.
Results indicate that prophylactic use of co-trimoxazole can reduce infection-related mortality in patients with new-onset anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis.
Expression of the Na+-K+-ATPase transmembrane ion transporter is upregulated in kidney-infiltrating B cells in lupus-prone mice and is a potential target for reducing renal B cell survival in patients with lupus nephritis.
A newly developed nanobody that simultaneously targets TNF and IL-6 has greater efficacy than individual targeting in rheumatoid arthritis disease-relevant preclinical models.
Neutrophil extracellular trap proteins trigger an accelerated form of osteoclastogenesis that is enhanced by the presence of carbamylated proteins and is linked to bone erosion.
A panel of serum biomarkers identified by proteomic analysis outperforms the best current alternatives for prediction of the progression of osteoarthritis.
Allogeneic transplantation of cartilage organoids derived from induced pluripotent stem cells promoted cartilage repair in a primate model without eliciting immune reactions.
Autoantibodies against rheumatoid arthritis (RA)-related peptides present in joints can be detected in the serum of patients with early RA using a multiplex immunoassay.
A new study identifies proteinase 3 as an important driver of granuloma formation in granulomatosis with polyangiitis and points to potential therapeutic approaches.
Analyses of data from the Danish national patient register show that diabetes mellitus increases the risk of end-stage renal disease in patients with systemic lupus erythematosus.
The IL-17A–IL-17F inhibitor bimekizumab is safe and effective for the treatment of both radiographic and non-radiographic axial spondyloarthritis, according to the results of two parallel phase III trials.
Age-related stiffening of the extracellular matrix in cartilage promotes chondrocyte ageing in an epigenetically controlled process involving repression of the longevity protein α-Klotho.
Blockade of iron uptake by the transferrin receptor CD71 can reduce metabolic dysregulation in T cells, resulting in amelioration of autoimmune pathology in lupus-prone mice.
IL-37 can delay intervertebral disc degeneration in rats by regulating the NF-κB pathway and ameliorating the senescence phenotype of nucleus pulposus cells.
IKKε, an upstream regulator of the NF-κB signalling pathway, mediates cartilage degradation in a mouse model of osteoarthritis and is a potential therapeutic target.
New research suggests that impaired synovial lymphatic function contributes to the pathogenesis of age-related osteoarthritis and could represent a new therapeutic target.
