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The highly anticipated NOR-SWITCH trial results provide valuable information for patients and physicians concerned about the effects of switching between a biologic agent and a biosimilar product. However, the possibility of frequent switches, potentially involving more than one biosimilar, raises more questions.
Pain in osteoarthritis (OA) can be resistant to the medical and surgical treatments currently in use. Local denervation of the arthritic joint could offer a new approach to relieve OA pain, if the results of a new cryoneurolysis clinical trial are confirmed.
The need to accurately assess the effectiveness of biologic therapies for rheumatoid arthritis in real-world settings has seen an explosion in nationwide biologics registers. In this Perspectives article, the authors discuss how to make the most of data from such registers.
This Review discusses the major insights gained from genetic studies in rheumatic diseases, such as genome-wide association studies, meta-analyses, fine-mapping and studies performed across different diseases and/or ethnicities, which have vastly increased our understanding of these diseases.
When considering the role of imaging in the management of symptomatic, peripheral joint osteoarthritis (OA) in clinical practice, clinicians should be aware that radiography has its drawbacks, and also consider that the use of advanced imaging techniques such as MRI should not be discouraged.
The presence of antinuclear antibodies (ANAs) is an important criterion for the classification of autoimmune diseases such as systemic lupus erythematosus, but the specificity of ANA tests is controversial. This Perspectives article critically discusses the methods used in ANA testing for different diseases, as well as ways to improve the use of these assays in clinical and research settings.
A growing body of evidence supports a shift away from bed rest and inactivity to prescribing physical activity for children and adolescents with rheumatic diseases. Increasing physical activity levels, as well as reducing hypoactivity, can improve symptoms and outcomes in this paediatric population.
The changing microbial and clinical profile of reactive arthritis suggests that rheumatologists need to reconsider the approach to its identification and treatment.
Necrotizing vasculitis is a classic lesion of polyarteritis nodosa (PAN) and a number of other disorders. This Perspectives article discusses how the characterization and understanding of PAN and related disorders has developed and enabled more-specific treatments.