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  • In this Review, the authors discuss age-related arthropathy and the similarities and differences between childhood loss of immune tolerance and adult development of immune-mediated arthritis, and develop three hypotheses describing age-related mechanisms that contribute to the onset of arthritis.

    • Yannick Degboe
    • Sebastiaan J. Vastert
    • Iain B. McInnes
    Review Article
  • New research attempts to explore the cause of plasmacytoid dendritic cell hyperactivation in systemic lupus erythematosus by focusing on genetic risk variation.

    • Jessica McHugh
    Research Highlight
  • This Review summarizes our understanding of sex- and gender-related differences in psoriatic arthritis, with a focus on disease progression and outcomes, underlying mechanisms and response to therapies.

    • Sanjana Tarannum
    • Ying-Ying Leung
    • Lihi Eder
    Review Article
  • The findings of a new study suggest that the adipokine FABP4 promotes multiple pathological changes in rheumatoid arthritis and could represent a new therapeutic target.

    • Sarah Onuora
    Research Highlight
  • A new study uncovers a protective role for epidermal S100A9 in psoriasis and psoriatic arthritis, and highlights this alarmin as a potential biomarker of disease progression.

    • Jessica McHugh
    Research Highlight
  • New research shows that annexin A1 has a protective role in periprosthetic osteolysis and could offer a therapeutic approach to this common cause of arthroplasty failure.

    • Sarah Onuora
    Research Highlight
  • In patients with autoimmune rheumatic disease, methotrexate therapy has been associated with poor immune response to vaccines, including those intended to provide protection against COVID-19. Emerging evidence supports the practice of temporarily discontinuing this treatment in order to improve immunogenicity.

    • Ana C. Medeiros-Ribeiro
    • Nadia E. Aikawa
    News & Views
  • Assessing systemic sclerosis (SSc) disease activity is challenging, and improved outcome measures are needed. This Review describes clinical and biochemical outcome measures of distinct features of SSc, with an emphasis on the dermatological manifestations and interstitial lung disease, including insights into biomarkers gained from single-cell RNA sequencing.

    • Robert Lafyatis
    • Eleanor Valenzi
    Review Article
  • Although the multitude of pathways involved in the pathogenesis of systemic lupus erythematosus (SLE) seem to be interconnected, each predominates in only a fraction of patients. This complexity means that many agents tested in SLE clinical trials — now including iberdomide — produce only a small clinical benefit.

    • Afroditi Boulougoura
    • George C. Tsokos
    News & Views
  • By isolating CD4+ T cells from patients with primary Sjögren syndrome, a new study has identified the involvement of a targetable interferon signalling pathway in T cell differentiation and B cell activation.

    • Robert Phillips
    Research Highlight
  • Transcriptomic analysis of synovial tissue from patients with rheumatoid arthritis and psoriatic arthritis reveals new details of the role of immune cell–stromal cell interactions in synovial inflammation.

    • Sarah Onuora
    Research Highlight
  • Individuals with chronic diseases that require constant medical support are particularly vulnerable during wartime and often remain so after the last shot has been fired. What consequences might the Russia–Ukraine war bring for rheumatology?

    • Bohdana Doskaliuk
    Comment