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  • Targeting inhibitor of apoptosis proteins (IAPs) ameliorates experimental ANCA-associated vasculitis, by enhancing fatty acid oxidation in neutrophils.

    • Sarah Onuora
    Research Highlight
  • New research suggests that A20 expressed in fibroblasts protects against fibrosis (whereas its negative regulator downstream regulatory element antagonist modulator (DREAM) promotes fibrosis), and highlights the therapeutic potential of targeting the A20–DREAM network.

    • Sarah Onuora
    Research Highlight
  • A gut bacterium found in people at risk of rheumatoid arthritis (RA) or with early RA is recognized by circulating autoantibodies, and is arthritogenic when it colonizes germ-free mice, suggesting a causal role in RA development.

    • Robert Phillips
    Research Highlight
  • Research related to the role of the synovium and its cell constituents during the pathogenies of osteoarthritis (OA) has taken a back seat to that of the cartilage and chondrocytes. The influence of synoviocytes in OA is increasingly recognized, but are synoviocytes equal in their contributions to disease progression?

    • Jason S. Rockel
    • Mohit Kapoor
    News & Views
  • Glycosylation is a common modification that can affect protein stability and interactions. In this Review, the authors discuss the role of glycosylation in rheumatic diseases, as well as the therapeutic potential of glycosylation-based interventions.

    • Theresa Kissel
    • René E. M. Toes
    • Manfred Wuhrer
    Review Article
  • The design of effective inhibitors of protein–protein interactions is challenging. In a new study, thermal fluctuation of protein structure was simulated to identify small-molecule candidates that inhibit protein–protein interactions. The application of this technique to other protein–protein interactions might facilitate the replacement of biologic agents with orally available small-molecule drugs.

    • Masashi Honma
    • Hiroshi Suzuki
    News & Views
  • New research demonstrates that unrestrained cutaneous growth of Staphylococcus aureus causes autoimmunity characteristic of systemic lupus erythematosus in mice.

    • Robert Phillips
    Research Highlight
  • Using a combination of various single-cell and immune profiling approaches, researchers have characterized the unique adaptive immune landscape of anti-melanoma differentiation-associated gene 5 antibody-positive (MDA5+) dermatomyositis.

    • Jessica McHugh
    Research Highlight
  • Contemporary guidelines for the management of systemic lupus erythematosus (SLE) recommend prescribing hydroxychloroquine dosages of 5 mg/kg per day or lower to minimize toxicity. However, new evidence raises serious concerns about the risk of SLE flare associated with such doses. How do the benefits and risks of this controversial recommendation balance out?

    • Tiphaine Lenfant
    • Nathalie Costedoat-Chalumeau
    News & Views
  • Various types of immune cells are dysregulated in systemic sclerosis and contribute to the initiation and progression of fibrosis. In this Review, the authors summarize various immune cell defects implicated in this disease that are current or potential targets for therapy.

    • Dan Fang
    • Beidi Chen
    • Rong Mu
    Review Article
  • In this Review, the authors describe the involvement of characteristic hallmarks of ageing in rheumatic diseases, suggesting that these chronic conditions can be considered to be diseases of premature or accelerated ageing, in which anti-ageing drugs may have therapeutic benefits.

    • Ghada Alsaleh
    • Felix C. Richter
    • Anna K. Simon
    Review Article
  • New research suggests therapies targeting neutrophil activation pathways could protect against arterial and venous thrombosis.

    • Sarah Onuora
    Research Highlight
  • Results from a study of CAR T cell therapy in five patients with treatment-refractory systemic lupus erythematosus demonstrate the induction of sustained drug-free disease remission.

    • Robert Phillips
    Research Highlight