Antibodies meeting a roadblock

Rheumatoid arthritis prevention in arthralgia: fantasy or reality?

  • Hanna W. van Steenbergen
  • Andrew P. Cope
  • Annette H. M. van der Helm-van Mil
Review Article


  • A crowd of people with two individuals highlighted in a different colour

    Keep up to date with changes to the conference calendar this year and find out which meetings will be attended by the editors of Nature Reviews Rheumatology.

  • Paper boats seen through a spyglass

    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews can help you stay up-to-date in your field

  • Knee x-ray of a 60 year old woman showing degenerative joint disease from osteoarthritis

    Osteoarthritis (OA) is a degenerative joint disease that leads to pain, stiffness and loss of function. It is the most common form of arthritis and one of the most prevalent musculoskeletal disorders worldwide. This collection from Nature Reviews Rheumatology brings together articles discussing the latest insights into the pathogenesis and management of OA.


  • Methotrexate reduces pain and stiffness in hand osteoarthritis with synovitis, according to the results of a new randomized controlled trial.

    • Jessica McHugh
    Research Highlight
  • Dual inhibition of glycolysis and glutaminolysis in fibroblast-like synoviocytes with a compound called c28MS shows promise in a mouse model of rheumatoid arthritis

    • Jessica McHugh
    Research Highlight
  • Biosimilars have an important place in the treatment of rheumatic conditions. The non-inferiority of biosimilars to bio-originators is ensured, but full and effective clinical adoption of these agents nonetheless requires consideration of several important issues, including the need for shared decision-making and a potential nocebo effect.

    • Rieke Alten
    • Max Weinbrecht-Mischkewitz
  • Chromatin accessibility of an enhancer that regulates the expression of a disease-associated microRNA is affected in monocytes from patients with systemic lupus erythematosus, highlighting this enhancer as a potential therapeutic target.

    • Robert Phillips
    Research Highlight
  • New research shows that a recombinant antibody that binds type II collagen protects against the development of arthritis in mice by blocking neutrophil recruitment.

    • Sarah Onuora
    Research Highlight
25 years of biologic therapy

25 years of biologic therapy

Biologic therapies with various modes of action have been introduced into the field of rheumatology over the past 25 years, and have revolutionized the treatment and outcomes in many rheumatic diseases. This collection from Nature Reviews Rheumatology brings together articles on biologic therapy in rheumatology, including the latest Reviews and Opinion pieces, as well as popular content from our archives.