Multicoloured balls sorted on a Galton board

Precision medicine in systemic lupus erythematosus

  • Serena Fasano
  • Alessandra Milone
  • Francesco Ciccia
Review Article


  • A crowd of people with two individuals highlighted in a different colour

    Keep up to date with changes to the conference calendar this year and find out which meetings will be attended by the editors of Nature Reviews Rheumatology.

  • Paper boats seen through a spyglass

    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews can help you stay up-to-date in your field

  • Damaged synovial joint surrounded by immune cellsnked by arrows

    This online collection contains articles from Nature Reviews Rheumatology that describe aspects of the epidemiology of rheumatic diseases that between them are important contributors to global morbidity and mortality.


  • A new treatment for osteoarthritis that combines cells from the patient in vitro prior to intra-articular injection has demonstrated beneficial effects on arthritic joints in a compassionate use study.

    • Robert Phillips
    Research Highlight
  • In a retrospective study, risk–benefit analyses suggest that primary prophylaxis against Pneumocystis jirovecii pneumonia is beneficial in patients receiving rituximab and high-dose glucocorticoids.

    • Sarah Onuora
    Research Highlight
  • In a retrospective study, biologic DMARD therapy was associated with faster control of immune checkpoint inhibitor-associated arthritis but also with a shorter time to cancer progression, compared with methotrexate therapy.

    • Sarah Onuora
    Research Highlight
  • Clinical and molecular analysis of autoantibodies against the endonuclease DNase1L3 in patients with systemic lupus erythematosus led to the identification of a subset of pathogenetic antibodies that are cross-reactive with double-stranded DNA.

    • Sarah Onuora
    Research Highlight
  • In screening for post-translational modifications associated with ankylosing spondylitis, researchers have identified a microbiome-metabolite-mediated modification that can lead to neoantigen generation and subsequent autoimmunity.

    • Jessica McHugh
    Research Highlight
Innate immune cells

Autoinflammatory disease

Autoinflammatory diseases encompass a variety of rare diseases caused by abnormal activation of the innate immune system. This collection from Nature Reviews Rheumatology brings together articles on the pathogenesis, treatment and definition of autoinflammatory disease