Nature Reviews Rheumatology

Synovial joint with rheumatoid arthritis

Focus: Immunology of rheumatoid arthritis

This Focus includes four specially commissioned Review articles that provide an in-depth look at the immunological processes underlying rheumatoid arthritis.

Featured

Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021

This Evidence-Based Guideline presents the latest treatment recommendations for medication selection in psoriatic arthritis (PsA), covering the six clinical domains of PsA, related conditions and associated comorbidities, and reflecting important advances in the field since the previous update.

Laura C. Coates
Enrique R. Soriano
the GRAPPA Treatment Recommendations domain subcommittees
Evidence-based Guidelines 27 Jun 2022
IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting

In this Review, the authors summarize the pathophysiological mechanisms of IL-1-mediated autoinflammation. They describe the epidemiological and clinical features of autoinflammatory diseases, challenges associated with diagnostics and disease management, and current and future therapies for targeting the IL-1 pathway.

Lori Broderick
Hal M. Hoffman
Review Article 21 Jun 2022
Mechanisms and clinical implications of intervertebral disc calcification

Intervertebral disc calcification is an often overlooked phenotype that can have considerable clinical consequences. In this article, the authors aim to raise awareness of intervertebral disc calcification and discuss its implications for the management and prognosis of degenerative spinal changes.

Uruj Zehra
Marianna Tryfonidou
Dino Samartzis
Review Article 09 May 2022

Current issue

Single-cell RNA sequencing sheds light on cell-type specific gene expression in immune cells

Sarah Onuora
Research Highlight 10 Jun 2022
Targeting UHRF1 in RA

Sarah Onuora
Research Highlight 07 Jun 2022
Skin inflammation precedes lesions in cutaneous lupus erythematosus

Robert Phillips
Research Highlight 24 May 2022
From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis

Hans Ulrich Scherer
Diane van der Woude
Rene E. M. Toes
Review Article 23 May 2022
Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission

Mariola Kurowska-Stolarska
Stefano Alivernini
Review Article 07 Jun 2022
Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications

Ursula Fearon
Megan M. Hanlon
Douglas J. Veale
Review Article 19 Apr 2022

Contents

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Announcements

Conference Calendar

Keep up to date with changes to the conference calendar this year and find out which meetings will be attended by the editors of Nature Reviews Rheumatology.
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Psoriatic disease

This online collection of News, Research, Review and Opinion from several Nature Portfolio journals contains articles with a particular focus on the pathogenesis and treatment of psoriatic disease, as well as the transition from psoriasis to psoriatic arthritis.

Latest Reviews & Analysis

- Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021
  
  This Evidence-Based Guideline presents the latest treatment recommendations for medication selection in psoriatic arthritis (PsA), covering the six clinical domains of PsA, related conditions and associated comorbidities, and reflecting important advances in the field since the previous update.
  
  Laura C. Coates
  Enrique R. Soriano
  Penelope Esther Palominos
  
  Evidence-based Guidelines 27 Jun 2022
- IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
  
  In this Review, the authors summarize the pathophysiological mechanisms of IL-1-mediated autoinflammation. They describe the epidemiological and clinical features of autoinflammatory diseases, challenges associated with diagnostics and disease management, and current and future therapies for targeting the IL-1 pathway.
  Lori Broderick
  Hal M. Hoffman
  
  Review Article 21 Jun 2022
- Mechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions
  
  In this Review, the authors provide an overview of the mechanisms contributing to joint damage in rheumatoid arthritis, particularly the interactions among immune cells, fibroblasts and bone, and discuss how this knowledge could inform the development of novel therapies.
  Noriko Komatsu
  Hiroshi Takayanagi
  
  Review Article 15 Jun 2022
- To choose or not? The value of discrete-choice experiments in rheumatology
  
  Do you inform patients about risks and chances of success associated with different choices when treatment needs to be changed? This approach takes time and requires patient health literacy. Results from a discrete-choice experiment in scleroderma lung disease add to the debate on shared decision-making.
  Janet E. Pope
  
  News & Views 09 Jun 2022
- Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission
  
  In this Review, the authors discuss the characterization of distinct synovial tissue macrophage (STM) populations and their functions in the context of the healthy and arthritic joint. They also describe how distinct STMs are specified, how they respond to danger signals and the clinical implications of understanding STM heterogeneity.
  Mariola Kurowska-Stolarska
  Stefano Alivernini
  
  Review Article 07 Jun 2022
- From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis
  Hans Ulrich Scherer
  Diane van der Woude
  Rene E. M. Toes
  
  Review Article 23 May 2022
- Towards the patient-centred care of rheumatoid arthritis
  Zara Izadi
  Gabriela Schmajuk
  
  News & Views 20 May 2022
- Improving the design of RCTs in non-radiographic axial spondyloarthritis
  Walter P. Maksymowych
  Robert G. W. Lambert
  Mikkel Østergaard
  
  Perspective 13 May 2022
- Mechanisms and clinical implications of intervertebral disc calcification
  Uruj Zehra
  Marianna Tryfonidou
  Dino Samartzis
  
  Review Article 09 May 2022

News & Comment

Semaphorin 3G exacerbates joint inflammation

Sarah Onuora
In Brief 27 Jun 2022
Low-dose glucocorticoids benefit seniors with RA

Sarah Onuora
In Brief 27 Jun 2022
Machine learning reveals antibody signature

Sarah Onuora
In Brief 27 Jun 2022
Pregnancy outcomes in SLE have not improved

Sarah Onuora
In Brief 27 Jun 2022
Single-cell RNA sequencing sheds light on cell-type specific gene expression in immune cells

Two new single-cell RNA sequencing studies provide insights into how disease-associated genetic variants influence gene expression in immune cells.

Sarah Onuora
Research Highlight 10 Jun 2022
Toward pre-treatment prediction of biologic DMARD response in RA

Results from the R4RA clinical trial indicate that gene signatures in pre-treatment biopsy-derived synovial tissue can predict the response to biologic DMARDs in patients with rheumatoid arthritis.

Robert Phillips
Research Highlight 07 Jun 2022

This online collection of articles from Nature Reviews Rheumatology contains Reviews, Opinion and News articles related to COVID-19, covering basic, translational and clinical aspects of COVID-19 in rheumatology as well as the impact of the pandemic on rheumatology practice and patient care.

Sarah Onuora

Collection 21 May 2021

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Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021

Kawasaki disease: pathophysiology and insights from mouse models

IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting

From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis

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