Biological classification of childhood arthritis: roadmap to a molecular nomenclature

  • Peter A. Nigrovic
  • Robert A. Colbert
  • Alberto Martini
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  • A paper in JCI Insight reports a role for antibody glycosylation in the pathogenesis of lupus nephritis and suggests CaMK4 as a potential urinary biomarker of active disease.

    • Joanna Clarke
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  • Two new studies have identified mutations in UBA1 associated with the newly identified condition VEXAS syndrome in cohorts of patients with relapsing polychondritis, supporting the concept that relapsing polychondritis is more than one disease.

    • Jessica McHugh
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  • New research suggests that advanced inflammatory arthritis could be treated with a targeted chemotherapeutic strategy to selectively induce apoptosis in osteoclasts and inflammatory macrophages in affected joints.

    • Sarah Onuora
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  • New findings link chronic type I interferon signalling with mitochondrial abnormalities in CD8+ T cells in systemic lupus erythematosus.

    • Jessica McHugh
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  • A study published in Immunity reveals the mechanism behind inflammatory tissue priming in chronic inflammatory arthritis.

    • Joanna Clarke
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  • Preclinical research suggests that inhibitors of PIM kinases currently in development in oncology could be repurposed for the treatment of early rheumatoid arthritis.

    • Sarah Onuora
    Research Highlight
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