Biological classification of childhood arthritis: roadmap to a molecular nomenclature

  • Peter A. Nigrovic
  • Robert A. Colbert
  • Alberto Martini
Review Article

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    • According to new data, overexpression of the nicotinamide adenine dinucleotide (NAD) hydrolase, CD38, in systemic sclerosis (SSc) leads to NAD depletion and fibrosis. These intriguing findings link inflammation, NAD metabolism and fibrosis and bare striking resemblance to age-related changes in SSc. Could DNA damage also connect these seemingly unrelated pathways?

      • Enrico Vittorio Avvedimento
      • Armando Gabrielli
      News & Views
    • The discovery that autoantibodies and other factors can predict the future onset of rheumatoid arthritis (RA) has encouraged the development of clinical trials looking at RA prevention. Although an exciting area of research, finding an approach that results in the successful completion of an RA prevention trial is challenging.

      • Liam J. O’Neil
      • Kevin D. Deane
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    • The transcription factor Sox9 is important for cartilage formation during development, but its role in postnatal growth plates and adult articular cartilage has been uncertain. New research is revealing essential roles for Sox9 in postnatal cartilage homeostasis and in preventing post-traumatic osteoarthritis, along with new mechanisms for chondrocyte-to-osteoblast transition.

      • Andrew A. Pitsillides
      • Frank Beier
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    • Salivary gland dysfunction is an important characteristic of primary Sjögren syndrome (pSS). In this Review, the authors discuss various epithelial abnormalities in pSS and the mechanisms by which epithelial cell–immune cell interactions contribute to disease development and progression.

      • Gwenny M. Verstappen
      • Sarah Pringle
      • Frans G. M. Kroese
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    • Type III interferons (IFNλs) affect innate and adaptive immune responses and are associated with the pathogenesis of autoimmune rheumatic diseases. In this Review, the authors provide an overview of IFNλs in rheumatic diseases and discuss therapeutic strategies to target them.

      • Rishi R. Goel
      • Sergei V. Kotenko
      • Mariana J. Kaplan
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  • A paper in JCI Insight reports a role for antibody glycosylation in the pathogenesis of lupus nephritis and suggests CaMK4 as a potential urinary biomarker of active disease.

    • Joanna Clarke
    Research Highlight
  • Two new studies have identified mutations in UBA1 associated with the newly identified condition VEXAS syndrome in cohorts of patients with relapsing polychondritis, supporting the concept that relapsing polychondritis is more than one disease.

    • Jessica McHugh
    Research Highlight
  • New research suggests that advanced inflammatory arthritis could be treated with a targeted chemotherapeutic strategy to selectively induce apoptosis in osteoclasts and inflammatory macrophages in affected joints.

    • Sarah Onuora
    Research Highlight
  • New findings link chronic type I interferon signalling with mitochondrial abnormalities in CD8+ T cells in systemic lupus erythematosus.

    • Jessica McHugh
    Research Highlight
  • A study published in Immunity reveals the mechanism behind inflammatory tissue priming in chronic inflammatory arthritis.

    • Joanna Clarke
    Research Highlight
  • Preclinical research suggests that inhibitors of PIM kinases currently in development in oncology could be repurposed for the treatment of early rheumatoid arthritis.

    • Sarah Onuora
    Research Highlight
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