Biological classification of childhood arthritis: roadmap to a molecular nomenclature

  • Peter A. Nigrovic
  • Robert A. Colbert
  • Alberto Martini
Review Article


  • Image of a crowd of people with two individuals highlighted in a different colour

    Keep up to date with changes to the conference calendar this year and find out which meetings will be attended by the editors of Nature Reviews Rheumatology.

  • Image of paper boats seen through a spyglass

    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews can help you stay up-to-date in your field


    • According to new data, overexpression of the nicotinamide adenine dinucleotide (NAD) hydrolase, CD38, in systemic sclerosis (SSc) leads to NAD depletion and fibrosis. These intriguing findings link inflammation, NAD metabolism and fibrosis and bare striking resemblance to age-related changes in SSc. Could DNA damage also connect these seemingly unrelated pathways?

      • Enrico Vittorio Avvedimento
      • Armando Gabrielli
      News & Views
    • The discovery that autoantibodies and other factors can predict the future onset of rheumatoid arthritis (RA) has encouraged the development of clinical trials looking at RA prevention. Although an exciting area of research, finding an approach that results in the successful completion of an RA prevention trial is challenging.

      • Liam J. O’Neil
      • Kevin D. Deane
      News & Views
    • The transcription factor Sox9 is important for cartilage formation during development, but its role in postnatal growth plates and adult articular cartilage has been uncertain. New research is revealing essential roles for Sox9 in postnatal cartilage homeostasis and in preventing post-traumatic osteoarthritis, along with new mechanisms for chondrocyte-to-osteoblast transition.

      • Andrew A. Pitsillides
      • Frank Beier
      News & Views
    • Salivary gland dysfunction is an important characteristic of primary Sjögren syndrome (pSS). In this Review, the authors discuss various epithelial abnormalities in pSS and the mechanisms by which epithelial cell–immune cell interactions contribute to disease development and progression.

      • Gwenny M. Verstappen
      • Sarah Pringle
      • Frans G. M. Kroese
      Review Article
    • Type III interferons (IFNλs) affect innate and adaptive immune responses and are associated with the pathogenesis of autoimmune rheumatic diseases. In this Review, the authors provide an overview of IFNλs in rheumatic diseases and discuss therapeutic strategies to target them.

      • Rishi R. Goel
      • Sergei V. Kotenko
      • Mariana J. Kaplan
      Review Article
Women’s health

Women’s health

Research into women’s health has suffered from historical neglect and lack of funding.

Nature Careers