Nanoparticles with a joint in the background

Engineering approaches for RNA-based and cell-based osteoarthritis therapies

  • Carlisle R. DeJulius
  • Bonnie L. Walton
  • Craig L. Duvall
Review Article


  • A crowd of people with two individuals highlighted in a different colour

    Keep up to date with changes to the conference calendar this year and find out which meetings will be attended by the editors of Nature Reviews Rheumatology.

  • Paper boats seen through a spyglass

    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews can help you stay up-to-date in your field

  • Knee x-ray of a 60 year old woman showing degenerative joint disease from osteoarthritis

    Osteoarthritis (OA) is a degenerative joint disease that leads to pain, stiffness and loss of function. It is the most common form of arthritis and one of the most prevalent musculoskeletal disorders worldwide. This collection from Nature Reviews Rheumatology brings together articles discussing the latest insights into the pathogenesis and management of OA.


    • Immunoengineering involves the design of materials with specific properties relating to the immune system. In this Review the authors consider the application of immunoengineering to systemic autoimmune diseases via site-specific and antigen-specific immunoregulation, the facilitation of immune cell therapy, novel approaches to immunodiagnostics and the generation of models to study autoimmunity.

      • David A. McBride
      • Ryan M. Jones
      • Nisarg J. Shah
      Review Article
    • The World Health Organization (WHO) has published new guidelines for the non-surgical management of chronic primary low back pain in adults in primary and community care settings. Although the guidelines are commendable, they lack guidance on when to suspect and how to avoid missing important secondary causes of back pain.

      • Mohamad Bittar
      • Atul Deodhar
      News & Views
    • Deep learning is a powerful technique with great potential for the analysis and interpretation of rheumatological images. To successfully use deep learning, rheumatologists should understand the tasks involved in image processing and the potential confounders and limitations that can affect the analysis of clinical data.

      • Berend C. Stoel
      • Marius Staring
      • Annette H. M. van der Helm-van Mil
      Review Article
    • Juvenile idiopathic arthritis treatment has evolved with new therapies, early remission goals and global efforts, including randomized trials and a treat-to-target strategy. This Review summarizes current evidence and therapeutic approaches to the management of non-systemic phenotypes of juvenile idiopathic arthritis.

      • Susan Shenoi
      • Gerd Horneff
      • Angelo Ravelli
      Review Article
    • This Review discusses the interplay of the gut microbiome and the immune system in the context of systemic lupus erythematosus. Dysbiosis and gut-barrier dysfunction are implicated in promoting disease and are potential therapeutic targets.

      • Gregg J. Silverman
      • Doua F. Azzouz
      • Abhimanyu Amarnani
      Review Article
  • Age-related B cells (ABCs) have pathogenic roles in autoimmune diseases. Research has now identified ZEB2 as the transcription factor that mediates differentiation into ABCs.

    • Robert Phillips
    Research Highlight
  • A meta-analysis of data from six genome-wide association study cohorts implicates several signalling pathways, including Hedgehog and Notch signalling, in Dupuytren disease.

    • Sarah Onuora
    Research Highlight
  • As in rheumatoid arthritis, achieving low disease activity or remission in psoriatic arthritis (PsA) remains a challenge and unmet need for many individuals. However, the complex pathogenesis, heterogeneity and varied tissue involvement in PsA mean that dedicated definitions and novel solutions are required for difficult-to-treat disease.

    • Stefan Siebert
    • Helena Marzo-Ortega
  • New research has shown that tryptophan metabolism is altered in patients with rheumatoid arthritis, and that correction of this metabolic alteration has a protective effect against collagen-antibody-induced arthritis in mice.

    • Robert Phillips
    Research Highlight
25 years of biologic therapy

25 years of biologic therapy

Biologic therapies with various modes of action have been introduced into the field of rheumatology over the past 25 years, and have revolutionized the treatment and outcomes in many rheumatic diseases. This collection from Nature Reviews Rheumatology brings together articles on biologic therapy in rheumatology, including the latest Reviews and Opinion pieces, as well as popular content from our archives.