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Molecular transport in articular cartilage — what have we learned from the past 50 years?

Latest Reviews

  • Review Article |

    Evidence from genetic, experimental and clinical studies has accumulated to indicate a role for the IL-17 pathway in the pathogenesis of spondyloarthritis. This Review discusses how IL-17A and IL-17F and their cellular sources contribute to the immunopathology of these diseases.

    • Leonie S. Taams
    • , Kathryn J. A. Steel
    • , Ushani Srenathan
    • , Lachrissa A. Burns
    •  & Bruce W. Kirkham
  • Review Article |

    Leukocytes travel through many different tissues during their lifetime, being educated by the cells and environments they encounter. An increased understanding of this journey in the context of rheumatoid arthritis offers hope for the development of future therapies.

    • Christopher D. Buckley
    •  & Helen M. McGettrick
  • Review Article |

    A growing body of evidence indicates that neutrophils and neutrophil extracellular traps (NETs) are involved in the progression of rheumatic diseases. This Review focuses on the role of NETs in systemic lupus erythematosus, vasculitis, rheumatoid arthritis and gout.

    • Falko Apel
    • , Arturo Zychlinsky
    •  & Elaine F. Kenny
  • Review Article |

    Vascular and obstetric antiphospholipid syndrome are associated with the same pathogenic antiphospholipid antibodies but differ with respect to their associated clinical manifestations. The expression and distribution of β2 glycoprotein I, the main target of antiphospholipid antibodies, might explain these differences.

    • Pier Luigi Meroni
    • , Maria Orietta Borghi
    • , Claudia Grossi
    • , Cecilia Beatrice Chighizola
    • , Paolo Durigutto
    •  & Francesco Tedesco
  • Review Article |

    Therapeutic application of cannabis remains controversial despite evidence of pain-relieving functions, particularly for rheumatic diseases. However, whether cannabis can also be used as an immunomodulatory therapeutic agent needs to be counterbalanced by risk assessment for adverse effects.

    • Daphna Katz-Talmor
    • , Itay Katz
    • , Bat-Sheva Porat-Katz
    •  & Yehuda Shoenfeld

News & Comment

  • News & Views |

    Large-scale genetic studies have highlighted the retinoic acid pathway as a contender in the pathogenesis of hand osteoarthritis. Functional studies are offering further insights into the role of retinoic acid that might translate into future therapies.

    • Helgi Jonsson
  • News & Views |

    A variety of biologic DMARDs now exist for the treatment of rheumatoid arthritis, but we don’t really know how these drugs function in vivo. Can time-lapse intravital imaging distinguish the modes of action of DMARDs by comparing response to joint destruction in mouse models of arthritis?

    • Maurizio Cutolo
    •  & Alberto Sulli
  • News & Views |

    Some patients with psoriatic arthritis are refractive to one biologic therapy but not to others, and a strategy for selecting the right therapy for each patient is needed. The findings of a new study highlight the potential benefit of stratifying patients by their immunophenotype to select the optimal biologic to use.

    • Hussein Al-Mossawi
    •  & Laura C. Coates


Systemic lupus erythematosus

This collection of articles from Nature Reviews Rheumatology, Nature Reviews Nephrology and Nature Reviews Disease Primers highlights progress in basic, translational and clinical research in SLE, including new insights into pathogenesis and identifying novel targets for therapy.

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