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Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair

Latest Reviews

  • Review Article |

    Neuropsychiatric systemic lupus erythematosus (NPSLE) remains highly challenging to diagnose and treat. This Review describes current understanding of its pathogenesis, along with novel therapies and diagnostic tools that could eventually improve the management of NPSLE.

    • Noa Schwartz
    • , Ariel D. Stock
    •  & Chaim Putterman
  • Review Article |

    Improved understanding of cell migration in the synovial joint, including the associated cellular and environmental factors, might reveal new therapeutic strategies for joint diseases such as rheumatoid arthritis and osteoarthritis and have important implications for tissue engineering of the joint.

    • Feini Qu
    • , Farshid Guilak
    •  & Robert L. Mauck
  • Perspective |

    Dactylitis is diffuse inflammation of the digits and is so closely associated with psoriatic arthritis that it can be used as an outcome measure of it. In this Opinion article, the authors describe how imaging modalities and scoring systems combined with data from animal models can be used to understand the underlying anatomy and immunopathogenesis of dactylitis.

    • Dennis McGonagle
    • , Ai Lyn Tan
    • , Abdulla Watad
    •  & Philip Helliwell
  • Review Article |

    Nakazawa and colleagues describe advances in our understanding of anti-neutrophil cytoplasmic antibody-associated vasculitis. These insights have already generated promising new treatments that target B cells, T cells and cytokines; potential novel approaches targeting additional cells or molecules are also discussed.

    • Daigo Nakazawa
    • , Sakiko Masuda
    • , Utano Tomaru
    •  & Akihiro Ishizu
  • Review Article |

    The treatment of systemic lupus erythematosus involves a balance between control of disease activity and prevention of therapeutic harm that requires careful optimization. In this Review, the authors discuss available and emerging therapeutic strategies that exploit the current drug armamentarium.

    • Mariele Gatto
    • , Margherita Zen
    • , Luca Iaccarino
    •  & Andrea Doria

News & Comment

Focus

Immunometabolism

Science Photo Library / ANDRZEJ WOJCICKI

Immunometabolism

The articles in this focus issue provide a general introduction to immunometabolism as well as a closer look at metabolite (dys)regulation in the setting of rheumatoid arthritis, systemic lupus erythematosus and osteoarthritis, and a forward-looking discussion of the possibility of targeting metabolic processes therapeutically.

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