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Advances in antibody engineering for rheumatic diseases

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Latest Reviews

  • Review Article |

    Next-generation sequencing (NGS) technologies are being developed at a rapid pace. This Review highlights advances in our understanding of rheumatic diseases that have been gained from NGS and offers guidance to rheumatology researchers using these technologies.

    • Laura T. Donlin
    • , Sung-Ho Park
    • , Eugenia Giannopoulou
    • , Aleksandra Ivovic
    • , Kyung-Hyun Park-Min
    • , Richard M. Siegel
    •  & Lionel B. Ivashkiv
  • Review Article |

    B cells contribute to the pathogenesis of many rheumatic diseases. Targeting immune checkpoints that control the activation and effector function of B cells represents a promising therapeutic avenue.

    • Samuel J. S. Rubin
    • , Michelle S. Bloom
    •  & William H. Robinson
  • Review Article |

    Osteoarthritis occurs spontaneously in pet dogs, which often share environmental and lifestyle risk-factors with their owners. This Review aims to stimulate cooperation between medical and veterinary research under the One Medicine initiative to improve the welfare of dogs and humans.

    • Richard L. Meeson
    • , Rory J. Todhunter
    • , Gordon Blunn
    • , George Nuki
    •  & Andrew A. Pitsillides
  • Review Article |

    Inclusion body myositis (IBM) is a slowly progressive disease characterized by unique clinical and pathological features. This Review discusses the historical and clinical aspects of IBM and the mounting evidence arguing for the important pathogenic function of the immune system.

    • Steven A. Greenberg
  • Review Article |

    Platelets mediate inflammatory responses by facilitating immune cell crosstalk and participating in inflammatory signalling cascades. In this Review, the authors discuss the emerging role of platelet signalling pathways in the pathogenesis of rheumatoid arthritis.

    • Oore-ofe Olumuyiwa-Akeredolu
    • , Martin J. Page
    • , Prashilla Soma
    •  & Etheresia Pretorius

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Key Advances in Medicine 2019

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