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Volume 19 Issue 1, January 2023

Synaptic degeneration in Alzheimer disease, inspired by the Review on p19.

Cover design: Philip Patenall

Research Highlights

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News & Views

  • In a study of 17,000 Medicare beneficiaries with mild cognitive impairment or dementia, non-Hispanic white older adults were more likely than Asian, Black or Hispanic older adults to have elevated cortical amyloid, as measured by PET. These findings have important implications for the use of amyloid-targeting therapies.

    • Heather E. Dark
    • Keenan A. Walker
    News & Views
  • A new study provides evidence for an association between COVID-19 and long-term neurological syndromes. The findings highlight the need for further research into the long-term neurological consequences of SARS-CoV-2 infection and the development of strategies that lessen the effects of these consequences on patient quality of life and on healthcare systems.

    • Alessandro Padovani
    • Andrea Pilotto
    News & Views
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  • In this Review, Savitz and Cox consider the evidence for a model of cell-based therapy referred to as the bioreactor hypothesis, in which exogenous cells migrate to peripheral organs and reprogramme host immune cells to generate an anti-inflammatory, regenerative environment.

    • Sean I. Savitz
    • Charles S. Cox Jr
    Review Article
  • Here, Spires-Jones and colleagues review our current understanding of the mechanisms underlying synaptic degeneration in Alzheimer disease and highlight key questions that still need to be answered. They also discuss novel therapeutic approaches that target the synapse.

    • Makis Tzioras
    • Robert I. McGeachan
    • Tara L. Spires-Jones
    Review Article
  • Amyotrophic lateral sclerosis (ALS) is a devastating, incurable disease characterized by progressive loss of upper and lower motor neurons. Here, the authors describe the current landscape of genetic therapies for ALS and discuss new opportunities for gene replacement therapy, focusing on loss-of-function mutations.

    • Ilaria Giovannelli
    • Adrian Higginbottom
    • Pamela J. Shaw
    Review Article
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  • Despite substantial research advances, treatment of neuropathic pain remains inadequate and responses to treatment are highly variable. In this Perspective, the authors argue that rational stratification of patients with neuropathic pain will aid identification of subgroups of patients who will benefit most from a given treatment.

    • Ralf Baron
    • Anthony H. Dickenson
    • David L. Bennett
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