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Internationally renowned neuropathologist and scientist John Q. Trojanowski died on 8th February 2022. John had an immeasurable impact on the field of neurodegenerative diseases and was responsible for many groundbreaking discoveries that continue to drive our understanding of these conditions.
A recent paper published in Nature reports on an ambitious project to construct standardized charts to aid recognition of typical and atypical development of the human brain.
The mechanistic contribution of cerebrovascular dysfunction to neurodegenerative diseases is difficult to determine. New single-cell transcriptomic analyses of human brain microvessels have identified transcriptomic signatures along the arteriovenous axis and transcriptional changes in the cerebrovasculature in Alzheimer disease and Huntington disease. This approach could advance our understanding of brain health and disease.
Analysis of brain images taken before and after infection with SARS-CoV-2 suggests that even mild COVID-19 is associated with brain structure alterations and cognitive impairment. However, the clinical implications for individuals are unclear and further studies are needed to assess the generalizability of the findings and whether the effects are long-lasting.
Some individuals accumulate high levels of Alzheimer disease neuropathological changes without showing symptoms of the disease. Here, the authors review the insights that have been gained from post mortem studies of such ‘resilient’ individuals and discuss the implications for risk prediction and the development of therapeutic interventions.
In this Review, the authors highlight the growing recognition that disruptions in cellular metabolism can be both a cause and a consequence of epileptic seizures and discuss how this emerging science might be exploited to develop innovative therapeutic strategies.
In this Review, Coyne and Rothstein discuss disruptions to the nuclear pore complex and nucleocytoplasmic transport, which are emerging as pathological mechanisms in multiple neurodegenerative diseases, and consider the effects of these changes on cellular function and their potential for therapeutic targeting.
The term ‘rapidly progressive dementia’ (RPD) describes a cognitive disorder with fast progression, leading to dementia within a relatively short time. This Review discusses the wide range of RPD aetiologies, as well as the diagnostic approach and treatment options.
