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A new case series describes a cohort of individuals with severe psychiatric presentations who were diagnosed with ‘possible’ or ‘probable’ autoimmune encephalitis on the basis of neurological examination. Many participants improved after treatment with immunotherapy, highlighting the importance of fostering a closer relationship between the fields of neurology and psychiatry.
Use of a proteomics approach has demonstrated that changes in protein expression association with Alzheimer disease are not always reflected in changes in RNA levels, highlighting the importance of directly studying proteomic changes to a full understanding of Alzheimer disease pathogenesis.
In this Review, the authors discuss recessive ataxias with ganglionopathy or polyneuropathy — particularly Friedreich ataxia and RFC1-associated cerebellar ataxia, neuropathy, vestibular areflexia syndrome — including the possible shared pathogenic mechanisms between these diseases and therapeutic advances.
Post-traumatic stress disorder (PTSD) is one of the few neuropsychiatric disorders for which the timing and cause of onset are understood, facilitating research into the underlying mechanisms. In this Review, Ressler and colleagues examine the neurobiology of PTSD, highlighting new insights from omics studies and discussing future directions of research.
In this Review, the authors discuss how various immunotherapies for neuroimmunological diseases interact with vaccination responses, including responses to SARS-CoV-2 vaccinations, and the implications for the safe and effective use of vaccines in patients with these diseases.
This Perspective highlights the importance of integrating cultural factors into dementia research and care. Focusing on minoritized groups in the USA, the authors explore the effects of culture on clinical evaluation, dementia risk, research and study recruitment, and caregiving practices.
