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The largest genome-wide association study of amyotrophic lateral sclerosis to date has identified new risk loci and provided insight into factors that influence susceptibility to the disease, highlighting the possibility that disease risk and disease progression are influenced by separate factors, with therapeutic implications.
Microglia are involved in many brain disorders, yet little is known about how genetic variants impact microglial function. A new study combined genome-wide association study data with the microglial transcriptomes of the same participants to reveal functional variants underlying brain disorders. This information will help to further mechanistic studies into disease-associated microglial changes.
In this Review, Fisher and Savitz consider how the era of reperfusion therapy in ischaemic stroke provides new hope for the development of cytoprotective therapies to further improve outcomes, highlighting how promising recent findings can be built on to benefit patients.
In vivo imaging biomarkers for early diagnosis and monitoring of Parkinson disease (PD) are important for the development of new therapies. The authors review recent advances in brain and retinal imaging in PD, focusing particularly on multimodal approaches with applications at the prodromal stage.
Glioblastoma is one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs, usually in or near the resection cavity. Here, the authors discuss local therapies for glioblastoma, examining treatment of the resection cavity and other direct approaches to the tumour.
In this Review, the authors discuss the involvement of astrocytes and microglia in the pathophysiology of progressive multiple sclerosis and consider current and future therapeutic approaches that directly target glial cells.
