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Volume 13 Issue 2, February 2017

Cover image supplied by David Fernandes-Cabral, Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. The corticospinal tract of the human brain on high-definition fibre tracking. The corticospinal tract, the longest white matter tract in the CNS, originates from the primary motor cortex, and crosses the internal capsule, brainstem and, finally, the spinal cord. Lesions such as brain tumours, arteriovenous malformations and strokes can displace, disrupt or infiltrate this tract. Advanced fibre tracking methods allow precise reconstruction of the tract, which can help improve outcomes after neurosurgical procedures.

Research Highlight

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In Brief

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Year in Review

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Review Article

  • The publication of a consensus definition of Parkinson disease (PD) psychosis in 2007 led to a rapid expansion of literature focusing on clinical aspects, mechanisms and treatment. The authors review this literature and discuss the evolving view of PD psychosis, from distinct classes of symptoms to a continuum progressing over the course of PD.

    • Dominic H. ffytche
    • Byron Creese
    • Dag Aarsland


    Review Article
  • Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting upper and lower motor neurons. Here, the authors outline previous and current efforts to characterize genes that are associated with ALS, and describe what is currently known about the genetic architecture of ALS.

    • Ammar Al-Chalabi
    • Leonard H. van den Berg
    • Jan Veldink
    Review Article
  • Real-world observational studies have the potential to answer questions about multiple sclerosis (MS) treatment that randomized controlled trials cannot. Trojano and colleagues discuss the pitfalls and necessary safeguards in observational studies, and the insights that such studies have provided into treatment decisions for patients with MS.

    • Maria Trojano
    • Mar Tintore
    • Helmut Butzkueven
    Review Article
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Science and Society

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