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Volume 10 Issue 6, June 2014

Cover image supplied by Carlos Barcia at the Institute of Neuroscience and School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Glial network in the human cortex. Astrocytes with their long processes are immunostained with GFAP antibodies, and microglia with their shorter processes are visualized with IBA1 antibodies. Glial cells form an extensive and uniform network along the brain parenchyma that is crucial for the correct functioning of the CNS. Research on glial cells provides important insights into the pathogenesis of many neurodegenerative diseases and neurological disorders.

Research Highlight

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In Brief

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Research Highlight

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In Brief

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News & Views

  • Medication overuse headache (MOH) is a widespread problem, and no global consensus has yet been reached regarding its management. In an attempt to address this issue, six headache centres have collaborated to evaluate a detoxification protocol in a large cohort of patients with MOH from Europe and South America.

    • Michael Bjørn Russell
    News & Views
  • A new consensus statement, written by an international panel of experts, seeks to standardize the use of neurosurgery for psychiatric disorders and to enhance patient safety. Although the approach is noble, some recommendations are overly conservative, whereas others might be more appropriate for regulatory authorities.

    • Veerle Visser-Vandewalle
    News & Views
  • A recent multicentre study has assessed the risk of relapse in patients with multiple sclerosis who switched from natalizumab to fingolimod treatment. Despite such efforts, no effective exit strategy from natalizumab treatment has yet been demonstrated for these patients.

    • Martin Stangel
    • Olaf Stüve
    News & Views
  • The effective assessment and treatment of pain in individuals with dementia carries substantial challenges. A recent study evaluating the presence and treatment of pain in individuals with or without dementia reveals valuable insights into analgesic prescribing practices and highlights critical factors to be addressed in dementia treatment.

    • Bettina S. Husebo
    • Anne Corbett
    News & Views
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Review Article

  • The average age of ischaemic stroke onset is decreasing, owing to a rise in the incidence of stroke among individuals under 50 years of age. In this article, the authors review the current literature on risk factors for and aetiology of 'young' ischaemic stroke. In addition, they discuss the lifelong implications of stroke in young adults, not only in terms of cardiovascular disease recurrence, but also with respect to psychosocial consequences, including cognitive and social impairments, mood disorders and fatigue.

    • Noortje A. M. M. Maaijwee
    • Loes C. A. Rutten-Jacobs
    • Frank-Erik de Leeuw
    Review Article
  • Despite varying aetiology, the clinical signs and symptoms of chronic distal symmetrical sensory peripheral neuropathies are similar. Gary Bennett and colleagues argue that this similarity arises from a common cause: mitochondrial injury. Various chemotherapeutic drugs, HIV-associated viral proteins and excess glucose can hamper mitochondrial function, thereby causing a chronic neuronal energy deficit, which manifests as spontaneous discharges and compartmental neuronal degeneration. Pharmacological protection from mitochondrial injury during chemotherapy, HIV treatment or in patients with diabetes could thus be used as an intervention for these potentially debilitating neuropathies.

    • Gary J. Bennett
    • Timothy Doyle
    • Daniela Salvemini
    Review Article
  • The fusion oncogene first discovered in patients with sarcomas,FUS, encodes a protein that pathologically accumulates in multiple neurodegenerative disorders. In this Review, Deng and colleagues discuss the involvement of various FUS mutations in amyotrophic lateral sclerosis, frontotemporal lobar degeneration and essential tremor, with particular emphasis on pathogenetic mechanisms. The authors argue that FUShas a general role in the neurodegenerative processes, and might therefore be a promising therapeutic target.

    • Hao Deng
    • Kai Gao
    • Joseph Jankovic
    Review Article
  • Ophthalmic findings are common features of neurodegenerative disorders, and have emerged as potentially useful biomarkers of disease progression in several conditions. Kersten et al. describe the various afferent visual system and other ophthalmic features of inherited neurodegenerative disorders, focusing on the expanding role of optical coherence tomography in diagnostic imaging of the retina and optic nerve head. They also discuss the ophthalmic manifestations and treatment implications of mitochondrial dysfunction—a feature of many inherited neurodegenerative diseases.

    • Hannah M. Kersten
    • Richard H. Roxburgh
    • Helen V. Danesh-Meyer
    Review Article
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